Results 111 to 120 of about 2,363,153 (402)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Strategies to Accelerate HIV Care and Antiretroviral Therapy Initiation After HIV Diagnosis: A Randomized Trial. [PDF]

, 2017
: Determine the effectiveness of strategies to increase linkage to care after testing HIV positive at mobile HIV testing in South Africa. : Unmasked randomized controlled trial.
Charalambous, S, Churchyard, GJ, Dowdy, DW, Fielding, KL, Ginindza, S, Hoffmann, CJ, Kubeka, G, Mabuto, T   +7 more
core   +2 more sources

Pre-hospital management protocols and perceived difficulty in diagnosing acute heart failure [PDF]

, 2020
Aim To illustrate the pre-hospital management arsenals and protocols in different EMS units, and to estimate the perceived difficulty of diagnosing suspected acute heart failure (AHF) compared with other common pre-hospital conditions.
Banaszewski, Marek, Bot, Emilie, Braun, Fracnois, Celutkiene, Jelena, Chouihed, Tahar, Christ, Michael, Claessens, Yann-Erick, Claret, Pierre-Geraud, Collins, Sean P., Cone, David C., Desmettre, Thibaut, Di Somma, Salvatore, Dunne, Robert B., Dupriez, Florence, Dyani, Mohammed, Escalada, Xavier, Ezekowitz, Justin, Freund, Yonathan, Goldstein, Patrick, Goodloe, Jeffrey M., Gregor, Roman, Guss, David, Hachimi Idrissi, Saïd, Han, Lim Swee, Harjola, Pia, Harjola, Veli-Pekka, Harrell, Andrew J., Hazlitt, Melissa, Hong, Rick, Hoppu, Sanna, Iirola, Timo, Knapp, Joshua M., Korgvee, Ago, Kruse, Nanna, Kuisma, Markku, Kurola, Jouni, Lainscak, Mitja, Laribi, Said, Leach, Robert, Lubin, Jeffrey S., Luk, Jeffrey H., Lund, Vesa, MacNeal, James, Makela, Pekka, Mansour, Cherif, Martikainen, Matti, Martin, Javier, Martin-Sanchez, Francisco J., McKinney, Jared, Mercer, Mary P., Metra, Marco, Meyer, Isabelle, Mimoz, Olivier, Miro, Oscar, Moeckel, Martin, Mols, Pierre, Montassier, Emmanuel, Penaloza, Andrea, Portela, Roberto C., Pruett, Kim, Pumputiene, Vanda, Rekosz, Jerzy, Reuter, Paul-Georges, Ricard-Hibon, Agnes, Rognas, Leif, Rosenberg, Paul, Sandberg, Marten, Swanson, Doug, Tarvasmaki, Tuukka, Tazarourte, Karim, Thys, Frederic, Torronen, Kari, Vannuffelen, Marc, Vermylen, Olivier, Weisberg, Stacy N., Weiss, Dale, Wilen, Susanna, Yee, Allen   +77 more
core   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

The cost-effectiveness of upfront point-of-care testing in the emergency department: a secondary analysis of a randomised, controlled trial

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2019
Background Time-saving is constantly sought after in the Emergency Department (ED), and Point-of-Care (POC) testing has been shown to be an effective time-saving intervention.
Lara Nicole Goldstein, Mike Wells, Craig Vincent-Lambert   +2 more
doaj   +1 more source

Evaluation of a training program for device operators in the Australian Government's Point of Care Testing in General Practice Trial: issues and implications for rural and remote practices [PDF]

, 2009
From September 2005 to February 2007 the Australian Government funded the Point of Care Testing (PoCT) in General Practice Trial, a multi-centre, cluster randomised controlled trial to determine the safety, clinical effectiveness, cost-effectiveness and ...
Bubner, Tanya, Gialamas, Angela, Laurence, Caroline O, Mazzachi, Beryl C, Shephard, Anne Kathryn, Shephard, Mark Douglas, Watkinson, Les   +6 more
core  

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Paper-Based Ratiometric Fluorescence Analytical Devices towards Point-of-Care Testing of Human Serum Albumin.

Angewandte Chemie, 2019
Monitoring of human serum albumin (HSA) in a point-of-care fashion is urgently needed in particular for elderly or chronically ill patients. Herein, we designed and synthesized a dual-state emissive chalcone probe having the feature of aggregation ...
Zijie Luo, Taoyuze Lv, Kangning Zhu, Yi Li, Lei Wang, J. Gooding, Guozhen Liu, B. Liu   +7 more
semanticscholar   +1 more source

Role of Point-of-Care Testing in Reducing Time to Treatment Decision-Making in Urgency Patients: A Randomized Controlled Trial [PDF]

, 2020
Introduction: Shortening emergency department (ED) visit time can reduce ED crowding, morbidity and mortality, and improve patient satisfaction. Point-of-care testing (POCT) has the potential to decrease laboratory turnaround time, possibly leading to ...
Chaisirin, Wansiri, Chakorn, Tipa, Laiwejpithaya, Sathima, Nakornchai, Tanyaporn, Pavichai, Rungrudee, Praphruetkit, Nattakarn, Rattanathummawat, Kavisara, Riyapan, Sattha, Ruangsomboon, Onlak, Thoesam, Tenzin, Wongkrajang, Preechaya   +10 more
core  

Implementation and Operational Research: The Effectiveness of Routine Opt-Out HIV Testing for Children in Harare, Zimbabwe. [PDF]

, 2015
OBJECTIVE: HIV testing is the entry point to access HIV care. For HIV-infected children who survive infancy undiagnosed, diagnosis usually occurs on presentation to health care services.
Bandason, Tsitsi, Dauya, Ethel, Ferrand, Rashida Abbas, Kidia, Khameer, Kranzer, Katharina, Meghji, Jamilah, Mujuru, Hilda, Mungofa, Stanley, Ncube, Getrude   +8 more
core   +1 more source