Results 131 to 140 of about 2,363,153 (402)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Real-Time Monitoring and Point-of-Care Testing: A Review of the Current Landscape of PrEP Adherence Monitoring

Patient Preference and Adherence, 2021
Alisse Hannaford,1 Yotam Arens,2 Helen Koenig2 1Department of Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; 2Division of Infectious Diseases, Hospital of the University of Pennsylvania, Philadelphia, PA ...
Hannaford A, Arens Y, Koenig H
doaj  

User interface design for mobile-based sexual health interventions for young people: Design recommendations from a qualitative study on an online Chlamydia clinical care pathway [PDF]

, 2015
Background: The increasing pervasiveness of mobile technologies has given potential to transform healthcare by facilitating clinical management using software applications.
Estcourt, C, Gibbs, J, Gkatzidou, V, Hone, K, Sadiq, ST, Sonnenberg, P, Sutcliffe, L, Szczepura, A   +7 more
core   +5 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

RAMPTM: A Rapid, Quantitative Whole Blood Immunochromatographic Platform for Point-of-Care Testing [PDF]

, 1999
Donald E. Brooks, Dana V. Devine, Paul C Harris, Joanne E Harris, Mark E. Miller, Andrew D Olal, Linda J Spiller, Zongen C Xie   +7 more
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Economic evaluation of point-of-care testing in the remote primary health care setting of Australia’s Northern Territory

ClinicoEconomics and Outcomes Research, 2018
Brooke A Spaeth,1 Billingsley Kaambwa,2 Mark DS Shephard,1 Rodney Omond3 1Flinders University International Centre for Point-of-Care Testing, Flinders University, Adelaide, SA, Australia; 2Health Economics Unit, College of Medicine and Public Health ...
Spaeth BA, Kaambwa B, Shephard MDS, Omond R   +3 more
doaj  

The use of point of care gastric ultrasound and anesthesia management in pediatric patients with preoperative fasting non-adherence scheduled for elective surgical procedures: a retrospective study

BMC Anesthesiology
Background Failure to adhere to perioperative fasting requirements increases aspiration risk and can lead to delay or cancellation of surgery. Point of care gastric ultrasound may guide decision-making to delay, cancel or proceed with surgery.
Marc D. Mecoli, Kirti Sahu, Joseph W. McSoley, Lori A. Aronson, Suryakumar Narayanasamy   +4 more
doaj   +1 more source

Does Point-of-Care Testing Reverse Centralization in Laboratory Medicine?. [PDF]

, 1999
Rainer Haeckel, Richard Fink
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source