In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications. [PDF]
Wang S, Cui X, Zhong Z, Zhang J.
europepmc +1 more source
Earthing effects on mitochondrial function: ATP production and ROS generation
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley +1 more source
Machine learning in point-of-care testing: innovations, challenges, and opportunities. [PDF]
Han GR+14 more
europepmc +1 more source
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo+4 more
wiley +1 more source
Point-of-care testing of hyponatremia and hypernatremia levels: An optoplasmonic biosensing approach. [PDF]
Hoque AMT+4 more
europepmc +1 more source
Genetic diversity and population structure of the Taigan dog breed
The Taigan is a rare sighthound from the mountains of Kyrgyzstan. We used DNA markers to study its genetic diversity and compare it with other sighthound breeds. Our findings show that the Taigan shares close genetic ties with the Kazakh Tazy, suggesting a common ancestry shaped by nomadic traditions and regional adaptation.
Kira Bespalova+10 more
wiley +1 more source
The Future of Point–of–Care Testing Using C-Reactive Protein – An Ideal Tool for Diagnosis, Prognosis and Therapy Management [PDF]
Eldri Prestegård
openalex +1 more source
Analysis of the regulation of undecaprenyl diphosphate dephosphorylation in Escherichia coli
BacA, PgpB, and YbjG phosphatases are involved in undecaprenyl phosphate (C55P) synthesis in Escherichia coli. We analyzed the lipid contents and the gene expression in the gene‐disruption strains. Undecaprenyl diphosphate (C55PP) level increased in the bacA, ybjG double‐disruption strain, but C55P levels were similar in all strains.
Tomotaka Jitsukawa+2 more
wiley +1 more source
A novel rapid rule-out protocol for acute chest pain using H-FABP point-of-care testing. [PDF]
Demirel O, Krainz M, Hoppe UC, Mirna M.
europepmc +1 more source