Results 301 to 310 of about 2,450,308 (424)

Real‐world genomic landscape of colon and rectal cancer

open access: yesFEBS Open Bio, Volume 15, Issue 4, Page 674-685, April 2025.
We confirmed enrichment of RTK alterations in patients with RAS/BRAF‐wt tumors and of PI3K pathway alterations in RAS/BRAF‐altered tumors with 51 982 real‐world tissue comprehensive genomic profiling (CGP) samples in CRC. In a subset of 140 patients with both tissue and liquid results, the sensitivity of liquid for results found by tissue was 100% when
Markus Schulze   +7 more
wiley   +1 more source

Cost‐effective and simple flow cytometry quantification of receptor‐mediated autophagy using fluorescent tagging

open access: yesFEBS Open Bio, Volume 15, Issue 4, Page 587-598, April 2025.
Mitophagy, the selective degradation of damaged mitochondria, is crucial for cellular health and function. This study introduces a rapid and efficient flow cytometry method using GFP‐BNIP3L/NIX to accurately quantify mitophagy. Our approach can be adapted to use any fluorescent‐tagged selective autophagy receptor, enabling direct and rapid analysis of ...
Mija Marinković   +3 more
wiley   +1 more source

Point-of-Care Testing for HIV: HIV Counselling and Testing

open access: yesCanadian Journal of Infectious Diseases, 2002
BL Johnston, JM Conly
doaj   +1 more source

Point of care testing for infectious diseases.

open access: yesClinica chimica acta; international journal of clinical chemistry, 2019
Hui Chen, Kengku Liu, Z. Li, Ping Wang
semanticscholar   +1 more source

Dexmedetomidine suppresses glucose‐stimulated insulin secretion in pancreatic β‐cells

open access: yesFEBS Open Bio, Volume 15, Issue 4, Page 634-646, April 2025.
Dexmedetomidine decreases insulin release and affects glucose metabolism; however, the specific mechanism remains largely unknown. This study shows clinically relevant doses of dexmedetomidine suppressed glucose‐stimulated insulin secretion. There was no significant difference in oxygen consumption rate, intracellular ATP levels, or caspase‐3/7 ...
Munenori Kusunoki   +5 more
wiley   +1 more source

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