Results 101 to 110 of about 128,076,263 (298)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Eagle Point Notice of Adopted Amendment (2008-01-24)

open access: yes, 2008
21 pp. Adopted 2008-01-24.
Eagle Point (Or.)
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Central Point Notice of Adopted Amendment (2006-10-26)

open access: yes, 2006
7 pp. Adopted 2006-10-26.
Central Point (Or.)
core  

Where To Go at the Next Timestamp

open access: yesData Science and Engineering
The next Point of Interest (POI) recommendation is the core technology of smart city. Current state-of-the-art models attempt to improve the accuracy of the next POI recommendation by incorporating temporal and spatial intervals or by partitioning the ...
Jiaqi Duan, Xiangfu Meng, Guihong Liu
doaj   +1 more source

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