Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang +6 more
wiley +1 more source
Annotated 3D Point Cloud Dataset of Broad-Leaf Legumes Captured by High-Throughput Phenotyping Platform. [PDF]
Galba A +10 more
europepmc +1 more source
FoldingNet: Interpretable Unsupervised Learning on 3D Point Clouds
Yaoqing Yang +3 more
openalex +1 more source
Forest understory trees revealed using sufficiently dense airborne laser scanning point clouds. [PDF]
Hamid Hamraz +2 more
openalex
Nanoscale Mapping of the Subcellular Glycosylation Landscape
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter +4 more
wiley +1 more source
Robotic Optical Coherence Tomography With Expanded Three-Dimensional Field-of-View Using Point-Cloud-Based Volumetric Montaging. [PDF]
Fang R +9 more
europepmc +1 more source
Hyperelastic Starch Hydrogel Configures Edible and Biodegradable All‐Components for Soft Robots
Hyperelastic starch hydrogel is tailored via a phase separation strategy of solvent‐antisolvent co‐modulation. The mechanical performance of starch hydrogel is widely tuned with maximum strains: 194.4–361.4%; maximum tensile stresses: 34–192 kPa; and Young's moduli: 36.0–205.8 kPa. Notably, the hydrogel achieves complete soil degradation within 24 days
Siyu Yao +7 more
wiley +1 more source
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan +9 more
wiley +1 more source
A Coarse-to-Fine Framework with Curvature Feature Learning for Robust Point Cloud Registration in Spinal Surgical Navigation. [PDF]
Zhang L +5 more
europepmc +1 more source
Indoor 3D wireframe construction from incomplete point clouds based on Gestalt rules
Zhiqiang Qin +7 more
openalex +1 more source

