Results 71 to 80 of about 6,190,166 (311)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A Novel Method for Density Analysis of Repaired Point Cloud with Holes Based on Image Data

Remote Sensing, 2021
Repairing point cloud holes has become an important problem in the research of 3D laser point cloud data, which ensures the integrity and improves the precision of point cloud data.
Yibo He, Zhenqi Hu, Kan Wu, Rui Wang
doaj   +1 more source

Three-Dimensional Point Cloud Semantic Segmentation for Cultural Heritage: A Comprehensive Review

Remote Sensing, 2023
In the cultural heritage field, point clouds, as important raw data of geomatics, are not only three-dimensional (3D) spatial presentations of 3D objects but they also have the potential to gradually advance towards an intelligent data structure with ...
Su Yang, M. Hou, Songnian Li
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Point Cloud Upsampling Network Incorporating Transformer and Multi-stage Learning Framework [PDF]

Jisuanji kexue
Drawing on Transformer’s powerful feature encoding capabilities in the fields of natural language and computer vision,and inspired by a multi-stage learning framework,a point cloud upsampling network that incorporates Transformer and multi-stage learning
LI Zekai, BAI Zhengyao, XIAO Xiao, ZHANG Yihan, YOU Yilin
doaj   +1 more source

CLASSIFICATION OF BIG POINT CLOUD DATA USING CLOUD COMPUTING [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015
Point cloud data plays an significant role in various geospatial applications as it conveys plentiful information which can be used for different types of analysis.
K. Liu, J. Boehm
doaj   +1 more source

Revisiting Stability Criteria in Ball‐Milled High‐Entropy Alloys: Do Hume–Rothery and Thermodynamic Rules Equally Apply?

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez, Alejandro F. Manchón‐Gordón, Antonio Vidal‐Crespo, Rafael Caballero‐Flores, Jhon J. Ipus, Clara F. Conde   +5 more
wiley   +1 more source

“Zero-Shot” Point Cloud Upsampling

2022 IEEE International Conference on Multimedia and Expo (ICME), 2022
Recent supervised point cloud upsampling methods are restricted by the size of training data and are limited in terms of covering all object shapes. Besides the challenges faced due to data acquisition, the networks also struggle to generalize on unseen records.
Zhou, Kaiyue, Dong, Ming, Arslanturk, Suzan   +2 more
openaire   +2 more sources

Enabling Digital Continuity in Virtual Manufacturing for Eco‐Efficiency Assessment of Lightweight Structures by Means of a Domain‐Specific Structural Mechanics Language: Requirements, Idea and Proof of Concept

Advanced Engineering Materials, EarlyView.
This article presents a solver‐agnostic domain‐specific language (DSL) for computational structural mechanics that strengthens interoperability in virtual product development. Using a hierarchical data model, the DSL enables seamless exchange between diverse simulation tools and numerical methods.
Martin Rädel, Andreas Schuster, Felix Schoenitz, Jean Lefèvre   +3 more
wiley   +1 more source