Results 71 to 80 of about 6,559,013 (333)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Adaptive Clustering for Point Cloud

Sensors
The point cloud segmentation method plays an important role in practical applications, such as remote sensing, mobile robots, and 3D modeling. However, there are still some limitations to the current point cloud data segmentation method when applied to ...
Zitao Lin, Chuanli Kang, Siyi Wu, Xuanhao Li, Lei Cai, Dan Zhang, Shiwei Wang   +6 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Three-Dimensional Point Cloud Applications, Datasets, and Compression Methodologies for Remote Sensing: A Meta-Survey

Sensors
This meta-survey provides a comprehensive review of 3D point cloud (PC) applications in remote sensing (RS), essential datasets available for research and development purposes, and state-of-the-art point cloud compression methods.
Emil Dumic, Luís A. da Silva Cruz
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Point Cloud Upsampling Network Incorporating Transformer and Multi-stage Learning Framework [PDF]

Jisuanji kexue
Drawing on Transformer’s powerful feature encoding capabilities in the fields of natural language and computer vision,and inspired by a multi-stage learning framework,a point cloud upsampling network that incorporates Transformer and multi-stage learning
LI Zekai, BAI Zhengyao, XIAO Xiao, ZHANG Yihan, YOU Yilin
doaj   +1 more source

Deep Learning Point Cloud Odometry

U.Porto Journal of Engineering, 2021
Achieving persistent and reliable autonomy for mobile robots in challenging field mission scenarios is a long-time quest for the Robotics research community. Deep learning-based LIDAR odometry is attracting increasing research interest as a technological
Bernardo Teixeira, Hugo Silva
doaj   +1 more source

Generalized Convolutional Neural Networks for Point Cloud Data

, 2017
The introduction of cheap RGB-D cameras, stereo cameras, and LIDAR devices has given the computer vision community 3D information that conventional RGB cameras cannot provide. This data is often stored as a point cloud.
Davis, Andrew, Savchenkov, Aleksandr, Zhao, Xuan   +2 more
core   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source