Results 201 to 210 of about 34,048 (263)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Characterization of the virus-host RNA-RNA interactome across important human pathogenic RNA viruses. [PDF]

PLoS Pathog
Damas ND, Seemann SE, Costa R, Krambrich J, Fossat N, Rivera-Rangel LR, Fahnøe U, Nielsen L, Gorodkin J, Bukh J, Scheel TKH.   +10 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

High-Precision Tunneling Magnetoresistance (TMR) Current Sensor for Weak Current Measurement in Smart Grid Applications. [PDF]

Micromachines (Basel)
Xu Y, Jin Z, Chen J.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Glass Microbubble Encapsulation for Improving the Lifetime of a Ferrofluid-Based Magnetometer. [PDF]

Micromachines (Basel)
Zhang C, Tadigadapa S.
europepmc   +1 more source

A leader-repeat hairpin blocks extraneous CRISPR RNA production in diverse CRISPR-Cas13 systems. [PDF]

EMBO J
Migur A, Feussner M, Liao C, Alkhnbashi OS, Chauvier A, Walter NG, Backofen R, Weinberg Z, Beisel CL.   +8 more
europepmc   +1 more source

Design and optical optimization of a 45 kW beam-down solar-thermal concentrator. [PDF]

Heliyon
Pujol-Nadal R, Guerreiro L, Cardona G.
europepmc   +1 more source

Protocol for culture, purification, and target validation of a hybridoma-generated monoclonal antibody targeting Aβ truncated species. [PDF]

STAR Protoc
Valle ML, Getaneh B, Loveland J, Erdjument-Bromage H, William C, Neubert TA, Rostagno A, Ghiso J.   +7 more
europepmc   +1 more source