Results 221 to 230 of about 199,997 (276)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Integrating climate scenarios and thermal welfare thresholds to project future heat stress risk in beef cattle. [PDF]

Int J Biometeorol
Grossi G, Vitali A, Lacetera N, Rossi C, Lacetera N.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

HIV low-level viraemia: considerations for prevention and treatment in an era of highly effective and durable antiretroviral therapy regimens. [PDF]

J Int AIDS Soc
Vojnov L, Bekker LG, Cohen MS, Jahn A, Havlir D, Boeras D, Ford N, Kumarasamy N, Broyles LN.   +8 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Indices of embodied Neuroergonomic coupling: a theory and hypothesis framework for quantifying brain-body-environment dynamics in built space. [PDF]

Front Hum Neurosci
Scanlin J.
europepmc   +1 more source

Using large language models to enhance clinically-driven missing data recovery algorithms in electronic health records. [PDF]

JAMIA Open
Lotspeich SC, Collins AN, Wells BJ, Khanna AK, Rigdon J, D'Agostino McGowan L.   +5 more
europepmc   +1 more source

High-accuracy quality control method of CT system couch tops for treatment planning via an advanced 3D coordinate measuring machine. [PDF]

J Appl Clin Med Phys
Yada R, Sakamoto M, Kurino N, Ueshima Y, Wang T, Sumida I, Nakamura K.   +6 more
europepmc   +1 more source