Results 171 to 180 of about 8,638,542 (419)

Design research, eHealth, and the convergence revolution [PDF]

open access: yesarXiv, 2019
The Quadruple Aim is a framework which prioritizes four aims, or dimensions of performance, for innovating in the healthcare domain, respectively: 1) enhancing the individual experience of care; 2) improving the work life of health care clinicians and staff; 3) improving the health of populations; and 4) reducing the per capita cost of care.
arxiv  

Regular review: Point of care testing

open access: yesBMJ, 2001
Point of care testing, otherwise referred to as near patient, bedside, or extra laboratory testing, is not new. Many of the early “diagnostic tests” were first done at the bedside—for example, urine testing. Over the past few years, however, analytical systems have been developed that enable a wide range of tests to be done quickly and simply without ...
Christopher P. Price   +1 more
openaire   +4 more sources

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Designing diagnostic platforms for analysis of disease patterns and probing disease emergence [PDF]

open access: yesarXiv, 2018
The emerging era of personalized medicine relies on medical decisions, practices, and products being tailored to the individual patient. Point-of-care systems, at the heart of this model, play two important roles. First, they are required for identifying subjects for optimal therapies based on their genetic make-up and epigenetic profile.
arxiv  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Factors determining patients' intentions to use point-of-care testing medical devices for self-monitoring: the case of international normalized ratio self-testing

open access: yesPatient Preference and Adherence, 2012
Syed Ghulam Sarwar Shah,1 Julie Barnett,1 Jasna Kuljis,2 Kate Hone,2 Richard Kaczmarski31Multidisciplinary Assessment of Technology Centre for Healthcare, 2Department of Information Systems and Computing, Brunel University London, Uxbridge, Middlesex, UK;
Shah SG   +4 more
doaj  

The interplay between the tumor microenvironment and tumor-derived small extracellular vesicles in cancer development and therapeutic response

open access: yesCancer Biology & Therapy
The tumor microenvironment (TME) plays an essential role in tumor cell survival by profoundly influencing their proliferation, metastasis, immune evasion, and resistance to treatment.
Xuanyu Guo   +4 more
doaj   +1 more source

On Wu and Schaback's Error Bound [PDF]

open access: yesarXiv, 2006
In this paper we point out that the commonly used error bound in the theory of radial basis functions contains an important error. It doesn't apply for derivatives. Thus one should be very careful when dealing with differential equations.
arxiv  

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

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