Results 81 to 90 of about 8,638,542 (419)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Consensus of the Study Group for Point-of-Care Lung Ultrasound in the intensive care management of COVID-19 patients

Anaesthesiology Intensive Therapy, 2020
Respiratory failure is a dominating medical issue in the severe course of COVID-19. Both at the stage of diagnostics prior to admission to the intensive care unit and during the monitoring of lesion evolution, diagnostic imaging techniques may ...
Natalia Buda, Paweł Andruszkiewicz, Mirosław Czuczwar, Wojciech Gola, Wojciech Kosiak, Piotr Nowakowski, Krystian Sporysz   +6 more
doaj   +1 more source

Integrated Optofluidic Sensor for Coagulation Risk Monitoring in COVID-19 Patients at Point-of-Care [PDF]

arXiv, 2020
While the pathophysiology underlying the COVID-19 infection remains incompletely understood, there is growing evidence to indicate that it is closely correlated to hypercoagulation among severely ill patients. Doctors may choose for use anti-coagulation doses to treat the patients at intensive care units. A rapid, easy, and low-cost solution to monitor
arxiv  

Handheld Point-of-Care Ultrasound Probes: The New Generation of POCUS

Journal of Cardiothoracic and Vascular Anesthesia, 2020
Recent advances in ultrasound technology have made ultrasound equipment more versatile, portable and accessible than ever. Modern hand-held, ultra-portable ultrasound devices have been developed by multiple companies and are contributing to make bedside ...
Y. Baribeau, A. Sharkey, O. Chaudhary, Santiago Krumm, Huma Fatima, Feroze Mahmood, R. Matyal   +6 more
semanticscholar   +1 more source

Point-of-care ultrasound in obstetrics and gynecology

Archives of Gynecology and Obstetrics, 2021
The rapid technical development and portability of ultrasound systems over recent years has had a profound impact on the area of point-of-care-ultrasound (POCUS), both in general medicine and in obstetrics and gynecology.
F. Recker, E. Weber, B. Strizek, U. Gembruch, S. Westerway, C. Dietrich   +5 more
semanticscholar   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

A Machine Learning System for Retaining Patients in HIV Care [PDF]

arXiv, 2020
Retaining persons living with HIV (PLWH) in medical care is paramount to preventing new transmissions of the virus and allowing PLWH to live normal and healthy lifespans. Maintaining regular appointments with an HIV provider and taking medication daily for a lifetime is exceedingly difficult.
arxiv  

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Clinical Evaluation of BD Veritor SARS-CoV-2 Point-of-Care Test Performance Compared to PCR-Based Testing and versus the Sofia 2 SARS Antigen Point-of-Care Test

Journal of Clinical Microbiology, 2020
The clinical performance of the BD Veritor System for Rapid Detection of SARS-CoV-2 nucleocapsid antigen (Veritor), a chromatographic immunoassay used for SARS-CoV-2 point-of-care testing, was evaluated using nasal specimens from individuals with COVID ...
S. Young, S. Taylor, C. Cammarata, Katey G. Varnado, Céline Roger-Dalbert, Amanda Montano, C. Griego-Fullbright, Cameron Burgard, Catherine Fernandez, K. Eckert, J. Andrews, H. Ren, J. Allen, R. Ackerman, Charles K. Cooper   +14 more
semanticscholar   +1 more source

Point-by-Point Progress: Gonorrhea Point of Care Tests

Expert Review of Molecular Diagnostics, 2020
Point-of-care (POC) tests for Neisseria gonorrhoeae (Ng) are urgently needed to control the gonorrhea epidemic, so patients can receive immediate diagnoses and treatment. While the advent of nucleic acid amplification tests (NAATs) has improved the accuracy of Ng identification, very few POC assays are able to provide results of such tests at the ...
Johan H. Melendez, Charlotte A. Gaydos
openaire   +4 more sources