Results 101 to 110 of about 2,814,147 (345)

Analysis Of The Relevance Of Models, Influencing Factors And The Point In Time Of The Forecast On The Prediction Quality In Order-Related Delivery Time Determination Using Machine Learning

Proceedings of the Conference on Production Systems and Logistics
One of the main objectives of manufacturing companies that structure their manufacturing system according to the workshop principle is to meet the delivery dates communicated to the customer. One approach to avoid large delivery time buffers to stabilize
Rokoss, Alexander, Popkes, Lennart, Schmidt, Matthias   +2 more
doaj   +1 more source

ApoE gene therapy: an overview and update [PDF]

, 2005
Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core  

HILT IV : subject interoperability through building and embedding pilot terminology web services [PDF]

, 2009
A report of work carried out within the JISC-funded HILT Phase IV project, the paper looks at the project's context against the background of other recent and ongoing terminologies work, describes its outcome and conclusions, including technical outcomes
Joseph, Anu, McCulloch, E., Nicholson, Dennis   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Less Than Ideal: The Reality of Implementing a Welfare-to-Work Program [PDF]

, 2001
As of December 1, 1999, Options/Opciones, the Center for Impact Research's pilot project designed to address the multiple needs of domestic violence victims who are trying to move off Temporary Assistance to Needy Families (TANF) and become self ...
Rebekah Levin
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Maternal serum levels of C-reactive protein at early pregnancy to predict fetal growth restriction and preterm delivery: A prospective cohort study

International Journal of Reproductive BioMedicine, 2020
Background: A considerable evidence suggests that maternal inflammation dysregulation may play as a risk factor for both maternal and neonatal outcomes. Objective: The study's objectives were designed to evaluate the correlation between serum C-reactive ...
Roshan Nikbakht, Elham Karimi Moghadam, Zeinab Nasirkhani   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The module configuration optimization of vertical computer numerical control honing machine based on ideal outranking cardinal point

Science Progress, 2020
To find the optimal one from all feasible module configuration schemes of high-end computer numerical control machine tools according to performance, cost, and delivery, this article studies the method of module configuration optimization.
Chuang Wang, Guanghui Zhou, Fengtian Chang, Yu Zhang   +3 more
doaj   +1 more source