Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
P2.012 Clinical Care Pathways Using Chlamydia and Gonorrhoea Tests Are Evolving: Point of Care Nucleic Acid Amplification Tests May Reduce Genitourinary Medicine Service Delivery Costs [PDF]
, 2013 Elisabeth J Adams +7 more
openalex +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
664: Preterm labor in twin gestations: a point of care test to identify impending preterm delivery and intra-amniotic infection [PDF]
, 2015 Kyung Joon Oh +2 more
openalex +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
A Dual Tandem Queue as a Model of a Pick-Up Point with Batch Receipt and Issue of Parcels
MathematicsParcel delivery networks have grown rapidly during the last few years due to the intensive evolution of online marketplaces. We address the issue of managing the operation of a network’s pick-up point, including the selection of the warehouse’s capacity ...
Alexander N. Dudin +3 more
doaj +1 more source
Online Food Delivery Sentiment Analysis from the Restaurant Point of View
, 2023 Anuar Sulaiman +3 more
openalex +2 more sources
Analyzing the efficiency differences among basic health units in Sargodha District [PDF]
Pakistan has adequate infrastructure for health services delivery at primary level. The study aims to calculate the technical efficiency of Basic Health Units (BHUs) in Sargodha by using the Data Envelopment Analysis (DEA) with the choice of inputs and ...
Abbas, Touqeer +3 more
core +1 more source