Results 221 to 230 of about 9,642,208 (359)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Bowel Preparation for Colonoscopy: The Patient Point of View.

Dig Dis
Tontini G, Spada C, Radaelli F, Testoni PA, Ciprandi G, Vecchi M.   +5 more
europepmc   +1 more source

Social egg freezing among single females: Middle Eastern point of view. [PDF]

Obstet Gynecol Sci
Sharaydih R, Akour A, Al-Sabbah H, AlMuhaissen SA.   +3 more
europepmc   +1 more source

Scale-dependent functions in statistical hydrodynamics: a functional\n analysis point of view [PDF]

, 1997
M. V. Altaĭsky
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Off-Label Treatment in Inflammatory Skin Diseases-European Point of View. [PDF]

J Clin Med
Sternicka J, Nowicki RJ, Bieniaszewski L, Purzycka-Bohdan D.   +3 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Asthma severity: the patient's point of view. [PDF]

Eur Clin Respir J
Guarnieri G, Olivieri B, Latorre M, Rizzi A, Blasi F, Canonica GW, Heffler E, Paggiaro P, Senna G, Caminati M, SANI study group.   +10 more
europepmc   +1 more source

The Problem of the Essence of Matriarchy from the Point of View of the Evolution of Human Intellect and Consciousness: Feminism and Promising Tools for the Formation of a Cognitive Society

Suleimenov Ibragim, Vitulyova Yelizaveta, Dinara Matrassulova   +2 more
openalex   +2 more sources