Results 231 to 240 of about 11,269,614 (288)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

POISSON POINT PROCESSES ATTACHED TO MARKOV PROCESSES

, 1972
openaire   +2 more sources

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Interrupted Point Processes

Biometrical Journal, 1979
AbstractA simple random thinning procedure for point processes is considered. The model is used for the description of a pattern generated by positions of tree seedlings.
openaire   +2 more sources

Pin-pointing APP Processing

Molecular Interventions, 2006
The neuropathological hallmarks of Alzheimer Disease (AD) are neurofibrillar tangles composed of tau protein and neuritic plaques containing the amyloid beta-peptide (Abeta) that is derived from proteolytic processing of the amyloid precursor protein (APP).
Thomas E, Willnow, Olav M, Andersen
openaire   +2 more sources

Networks, Point Processes, and Networks of Point Processes

2020
I consider two classes of statistical models: networks and point processes. These random structures are oftenused in situations where traditional statistical assumptions do not hold (e.g. the data are not independent or identically distributed), meaning extra care must be taken to develop and extend statistical theory and tools to these settings.
openaire   +1 more source

Markov Point Processes

Journal of the London Mathematical Society, 1977
Ripley, B. D., Kelly, F. P.
openaire   +1 more source

Point Processes.

Journal of the Royal Statistical Society. Series A (Statistics in Society), 1991
Fergus Daly, D. R. Cox, V. Isham
openaire   +1 more source

Basics of Stochastic Processes, Point and Marked Point Processes

2015
The study of the dynamic performance of engineered systems subject to uncertainty requires the use of tools from stochastic processes. Although stochastic processes have been used extensively in many disciplines (e.g., see [1, 2, 3, 4]), this chapter will focus on the the mathematical background that supports the models presented later in the book. The
Mauricio Sánchez-Silva, Georgia-Ann Klutke   +1 more
openaire   +1 more source