Results 111 to 120 of about 28,661,875 (311)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Non-uniform changes in different categories of precipitation intensity across China and the associated large-scale circulations

Environmental Research Letters, 2019
This study focuses on changing trends in precipitation across mainland China during the period 1957–2014. We explore the influence of the El Niño–Southern Oscillation (ENSO), the Pacific Decadal Oscillation (PDO), and related large-scale atmospheric ...
Chiyuan Miao, Qingyun Duan, Qiaohong Sun, Xiaohui Lei, Hu Li   +4 more
doaj   +1 more source

Natural catastrophes and point-like processes Data handling and prevision

Annals of Geophysics, 1998
A frequent approach when attempting to manage a natural catastrophe is in terms of a numerical model, by which we try to forecast its occurrence in space and time. But, sometimes this is difficult or even unrealistic.
G. P. Gregori
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Change-Point Detection in Multivariate Categorical Processes With Variable Selection

IEEE Access, 2019
Statistical process control (SPC) has been widely used to control and improve the quality of products in manufacturing processes. Currently, a limited number of schemes is available for change-point detection in multivariate categorical processes (MCPs),
Qing He, Weiyan Liu, Junjie Wang
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Quantum bioelectrochemical (QBIOL) software based on point stochastic processes

Communications Chemistry
Bioelectrochemistry is crucial for understanding biological functions and driving applications in synthetic biology, healthcare, and catalysis. However, current simulation methods fail to capture both the stochastic nature of molecular motion and ...
Simon Grall, Ignacio Madrid, Aramis Dufour, Helen Sands, Masaki Kato, Akira Fujiwara, Soo Hyeon Kim, Arnaud Chovin, Christophe Demaille, Nicolas Clément   +9 more
doaj   +1 more source

Modeling Terror Attacks with Self-Exciting Point Processes and Forecasting the Number of Terror Events. [PDF]

Entropy (Basel), 2023
Wang S, Wang X, Li C.
europepmc   +1 more source