Results 171 to 180 of about 8,099,068 (351)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Experimental Study on Spread and Burning Characteristics of Continuous Spill Fire Leaked from a Point Source under Different Slopes. [PDF]

Int J Environ Res Public Health, 2023
Sun X, Huang H, Zhao J, Zhang X, Song G.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Numerical Simulation Study on Spatial Diffusion Behavior of Non-Point Source Fugitive Dust under Different Enclosure Heights. [PDF]

Int J Environ Res Public Health, 2023
Guo J, Lin W, Li H, Zhang Z, Qin X.
europepmc   +1 more source

The influence of Crowding on DENIS point source detection rates [PDF]

, 1994
A.C. Robin, Andr�s Holl, Erik Deul, T.J. Davidge   +3 more
core   +1 more source

Excitation of normal modes of a weakly inhomogeneous waveguide by a point source [PDF]

, 1986
N. A. Razumovskii
openalex   +1 more source

CTbend: A Bayesian open-source framework to model pointing corrections for Cherenkov telescopes [PDF]

, 2021
G. Spengler, U. Schwanke, Д. Журов
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effects of Policy for Controlling Agricultural Non-Point Source Pollution in China: From a Perspective of Regional and Policy Measures Differences. [PDF]

Int J Environ Res Public Health, 2023
Hua C, Zhang J, Long Z, Woodward RT.
europepmc   +1 more source

Testing secret interaction with astrophysical neutrino point sources [PDF]

C. Döring, Stefan Vogl
openalex   +1 more source