Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Mechanisms mediating false codling moth, Thaumatotibia leucotreta (lepidoptera: Tortricidae), mating disruption using point-source pheromone dispensers. [PDF]
Steyn VM +3 more
europepmc +1 more source
Optimizing Green-Gray Infrastructure for Non-Point Source Pollution Control under Future Uncertainties. [PDF]
Dong X, Yuan P, Song Y, Yi W.
europepmc +1 more source
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Achieving green agricultural development: Analyzing the impact of agricultural non-point source pollution on food security and the regulation effect of environmental regulation. [PDF]
Xu M, Lu Z.
europepmc +1 more source
Minimalizing Non-point Source Pollution Using a Cooperative Ion-Selective Electrode System for Estimating Nitrate Nitrogen in Soil. [PDF]
Su R +10 more
europepmc +1 more source
Eddy covariance methane flux measurements over a grazed pasture: effect of cows as moving point sources [PDF]
Raphael Felber +3 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Quantifying variation of non-point source pollution and its impact factors: A study of Nansi Lake Basin. [PDF]
Liu J +8 more
europepmc +1 more source

