Results 101 to 110 of about 19,001,244 (290)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A New Method for Determining Optimal Regularization Parameter in Near-Field Acoustic Holography

Shock and Vibration, 2018
Tikhonov regularization method is effective in stabilizing reconstruction process of the near-field acoustic holography (NAH) based on the equivalent source method (ESM), and the selection of the optimal regularization parameter is a key problem that ...
Yue Xiao
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Novel DOA Estimation Method for a Far-Field Narrow-Band Point Source via the Conventional Beamformer

Journal of Marine Science and Engineering
Far-field narrow-band Direction-of-Arrival (DOA) estimation is a practical challenge in passive and active sonar applications. While the Conventional Beamformer (CBF) is a robust Maximum Likelihood Estimator (MLE), its precision is inherently constrained
Xuejie Dai, Shuai Yao
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Cost-Effectiveness of Alternative Environmental Policies for Reducing Non-Point Source Pollution in Public Water Supplies [PDF]

This study predicts farmers' response to policy alternatives aimed at alleviating non-point source pollution problems in a municipal water supply in Pike County, Illinois.
Mafoua, Edouard, Hornbaker, Robert H.
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Central Point Notice of Adopted Amendment (2008-10-20)

, 2008
40 pp. Adopted 2008-10-20. Department of Land Conservation and Development Notice of Adopted AmendmentThe proposed amendment is the City of Central Point Buildable Lands Inventory (BLI) which will be a component of the updated Land Use Element of the ...
Central Point (Or.)
core  

Design of a smooth freeform illumination system for a point light source based on polar-type optimal transport mapping

, 2017
A design method is proposed to generate smooth freeform illumination optics for a point light source based on the L-2 optimal transport (LOT) mapping. In this method, the LOT mapping between an assumed circular planar source and a prescribed target is ...
Songbo Xu, Xu, Songbo, Hu, Xinrong, Xinrong Hu, Mao, Xianglong, Xianglong Mao, Xie, Yongjun (yjxie@opt.ac.cn), Yongjun Xie, Xie, Yongjun   +8 more
core   +1 more source

Development and application of cobalt source layout interface program for gamma irradiation device

Fushe yanjiu yu fushe gongyi xuebao
This study uses the MATLAB App Designer software based on the principles of point kernel integration and the Monte Carlo method to design an interface program for the cobalt source layout effect of gamma irradiation equipment.
LIU Jiangping, CHEN Qiang
doaj   +1 more source