Results 201 to 210 of about 19,001,244 (290)

moTSart: accelerating automated transition state search with generative models in a low-data regime.

Digit Discov
Galustian L, Karwounopoulos J, Demuth T, De Landsheere J, Mark K, Kovar MP, Zamyatin A, Svatunek D, Heid E.   +8 more
europepmc   +1 more source

Contour-Based Chain-Code Serialization for Lossless Compression of Voxelized 3D Objects. [PDF]

Entropy (Basel)
Durán-Yáñez EA, Rodríguez-Díaz MA, Mendoza-González R, Luna-Rosas FJ, Martínez-Romo JC.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

A Monte Carlo based dose verification tool for an HDR Ir-192 brachytherapy source and its evaluation on extremity malignancies. [PDF]

J Appl Clin Med Phys
Li P, Kong CW, Zhang R, Zhou D, Huang C, Chiu TL, Nam PH, Yung CT, Chang TY, Yu SK, Yang B.   +10 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

SDA-Reg: large-scale dynamic scene point cloud registration with semantic dual-stream attention. [PDF]

Sci Rep
Fu S, Cai Q, Yao Z, Chen Q, Lin T.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Identifying spatiotemporal hotspots and sources of small-middle riverine nitrogen pollution using intensive field sampling and export coefficient model. [PDF]

PeerJ
Zhang Z, Ma R, Su G, Fan Y, Wang S, Sun J, Wang T.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source