Results 131 to 140 of about 492,052 (313)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Humanoid Humeral Pointing Kinematics
, 2002 Humanoid humeral pointing kinematics is implemented in a humanoid robotic shoulder complex consisting of a parallel mechanism as the innermost shoulder girdle and a serial mechanism as the outermost spherical glenohumeral joint.
Michael Stanišić +5 more
core +1 more source
PERBANDINGAN POINTING JONGKOK DENGAN POINTING BERDIRI DALAM OLAHRAGA PETANQUE PADA BKMF PETANQUE FIK UNM [PDF]
, 2020 Andi Pahria Juliana, 2020. Perbandingan Pointing Jongkok Dengan Pointing Berdiri Dalam Olahraga Petanque Pada BKMF Petanque FIK UNM. Jurusan Pendidikan Jasmani Kesehatan dan Rekreasi. Fakultas Ilmu Keolahragaan.
JULIANA, ANDI PAHRIA
core
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
IEEE AccessGestures play a pivotal role in human communication, often serving as a preferred or complementary medium to verbal expression due to their superior spatial reference capabilities.
Eran Beeri Bamani +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Object center of mass predicts pointing endpoints in virtual reality
Frontiers in Virtual RealityIntroductionHumans point using their index finger to intuitively communicate distant locations to others. This requires the human sensorimotor system to select an appropriate target location to guide the hand movement. Mid-air pointing gestures have been
Immo Schuetz +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source