Results 51 to 60 of about 15,531,165 (394)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Post-Mortem Analysis of Diazinon and its major Metabolite, 2-isopropyl-4- methyl-6-hydroxypyrimidine, in a Case of Fatal Diazinon Ingestion

Arab Journal of Forensic Sciences & Forensic Medicine, 2019
This case report describes a detection and quantitation method for diazinon and its major metabolite, 2-isopropyl-4-methyl-6-hydroxypyrimidine (IMHP), in postmortem blood and tissue samples from a fatal case of diazinon ingestion.
Ibraheem M. Attafi, Magbool E oraiby, Mohsen M Fageeh, Ghassam A Shaikhain, Mohammed Y Albeishy, Ibrahim A Khardali, Mohammed A. Hakami   +6 more
doaj   +1 more source

Metformin overdose: A serious iatrogenic complication—Western France Poison Control Centre Data Analysis

Basic & Clinical Pharmacology & Toxicology, 2019
The prevalence of type 2 diabetes (T2D) continues to rise across the world. Metformin is still considered the “gold standard” and is, therefore, increasingly prescribed.
Alexandre Stevens, J. Hamel, Ali Touré, S. Hadjadj, D. Boels   +4 more
semanticscholar   +1 more source

Integrated control of vector-borne diseases of livestock--pyrethroids: panacea or poison?

, 2003
Tick- and tsetse-borne diseases cost Africa approximately US$4-5 billion per year in livestock production-associated losses. The use of pyrethroid-treated cattle to control ticks and tsetse promises to be an increasingly important tool to counter this ...
Coleman, Paul G, Eisler, Mark C, Machila, Noreen, Morton, John F, Torr, Stephen J   +4 more
core   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

A rare symptom of foodborne botulism: dysgeusia. Case report and clinical review

Emergency Care Journal
Clostridium botulinum has become one of the most well-known microorganisms in medical history, thanks to both fatal botulism epidemics and the recent medical use of botulinum neurotoxin.
Simone Esposito, Francesco Coletta, Giovanna Di Maiolo, Filomena Lo Chiatto, Pasquale Rinaldi, Anna Lanza, Getano Panico, Crescenzo Sala, Antonio Tomasello, Romolo Villani   +9 more
doaj   +1 more source

Morphology and phylogeny identify two new species and one new subspecies of Podoscypha from Yunnan Province, Southwest China

Frontiers in Microbiology, 2023
In this study, Podoscypha was taxonomically and phylogenetically evaluated. In total, five specimens collected from the tropical areas of Yunnan Province in Southwest China were studied.
Jing Si, Yi-Zhe Zhang, Jia-Qi Liang, Hai-Jiao Li   +3 more
doaj   +1 more source

Detecting a signal in the noise : Monitoring the global spread of novel psychoactive substances using media and other open source information [PDF]

, 2015
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no ...
Canadian Community Epidemiology Network On Drug Use, Center for Substance Abuse Research, European Monitoring Centre For Drugs And Drug Addiction, Sumnall H   +3 more
core   +1 more source

Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities

Annals of Clinical and Translational Neurology, EarlyView.
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski, Freddy Chafota, Fangyuan Cao, Amanda Wei Yin Lim, Victor Flores‐Ocampo, Santiago Díaz‐Torres, Zuriel Ceja, Luis M. García‐Marín, Scott F. Farrell, Kishore R. Kumar, Jane Alty, George D. Mellick, Trung Thành Ngô, Miguel E. Rentería   +13 more
wiley   +1 more source

Not only Van Gogh: a case of BRASH syndrome with concomitant digoxin toxicity

Journal of Medical Case Reports
Background Bradycardia, renal failure, atrioventricular (AV) node blocking, shock, and hyperkalemia syndrome is a potentially life-threatening clinical condition characterized by bradycardia, renal failure, atrioventricular (AV) node blocking, shock, and
Ilaria Costantini, Giovanni Mantelli, Massimo Carollo, Lorenzo Losso, Elia Morando, Matilde Bacchion, Mariapaola Castri, Lucia Drezza, Giorgio Ricci   +8 more
doaj   +1 more source