Results 181 to 190 of about 145,792 (335)

5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux

open access: yesAdvanced Science, EarlyView.
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li   +24 more
wiley   +1 more source

The Powerful Antitakeover Force of Staggered Boards: Theory, Evidence and Policy [PDF]

open access: yes
Staggered boards, which a majority of public companies now have, provide a powerful antitakeover defense, stronger than is commonly recognized. They provide antitakeover protection both by (i) forcing any hostile bidder, no matter when it emerges, to ...
Guhan Subramanian   +2 more
core  

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

open access: yesAdvanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo   +13 more
wiley   +1 more source

Gamma and neutron dose measurements for a thermal tungsten nuclear rocket critical experiment [PDF]

open access: yes
Measurements of gamma and neutron dose distributions in core of thermal tungsten nuclear rocket ...
Houghton, G. K.   +2 more
core   +1 more source

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

open access: yesAdvanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez   +20 more
wiley   +1 more source

Unveiling Alkali‐Induced Redox Modulation: In‐Situ Spectroscopic Insights from RWGS on Alkali‐Modified ZrO2‐Supported Cu Catalysts

open access: yesAdvanced Science, EarlyView.
Revisiting the prevailing views that alkali only enhances adsorption properties and stabilizes metal particles against sintering, this study highlights the key role of Na+ in modulating Cu redox properties. Na+ added via wet impregnation (WI) hinders Cu2+ reduction but promotes oxidation and leads to Cu site loss by sintering/coverage. In contrast, the
Abdallah I. M. Rabee   +10 more
wiley   +1 more source

The Achievements of the Poison Control Center of Bach Mai Hospital, Vietnam [PDF]

open access: yesAsia Pacific Journal of Medical Toxicology, 2013
Pham Due, Nguyen Nguyen
doaj  

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