Results 31 to 40 of about 50,780 (252)
Toxicology CommunicationsBackground Poisoning is an important public health issue. The English Index of Multiple Deprivation (IMD) is a socioeconomic analytical tool that can be used to explore population level inequalities at neighbourhood level. We undertook a pilot assessment
Pardeep S Jagpal +4 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications
Biosensors, 2019 This article critically discusses the latest advances in the use of voltammetric, amperometric, potentiometric, and impedimetric biosensors for forensic analysis.
Paloma Yáñez-Sedeño +3 more
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The Ring RPT Method for DH Systems Containing Dispersed Particle-Type of Fuel and Burnable Poisons
Frontiers in Energy Research, 2021 Because dispersed particle-type fuel and burnable poisons both have double heterogeneity (DH), using the traditional volumetric homogenization method (VHM) to treat DH systems will bring about large reactivity calculation deviation.
Lei Lou +6 more
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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Consistency of Cultivation and Environmental Objectives [PDF]
پژوهشهای اقتصادی, 2009 Intensive usage of farm inputs has resulted in environment pressure. The pressure is mainly due to the widely use of chemical inputs and the overdraft of groundwater resources.
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
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Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
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Polarizable Vanadium Dipoles Promote Water Dissociation on Vanadium‐Based Metal Organic Framework
Advanced Functional Materials, EarlyView.The polarization of unpaired V 3d electrons weakens the H─O bond to improve water dissociation by the dual Vδ+:O─H and Pλ−:H─O coupling hydrogen bonds formation and relaxation. P@V‐MOF electrocatalyst shows low overpotentials (94 mV in acid, 178 mV in neutral, and 77 mV in alkaline solutions) with excellent stability for effective overall water ...
Xinjuan Liu +13 more
wiley +1 more source