Results 241 to 250 of about 400,590 (330)

Balancing High Densities and Conservation Targets to Optimise Koala Management Strategies. [PDF]

Ecol Evol
Saltré F, Peters KJ, Rogers DJ, Chadoeuf J, Weisbecker V, Bradshaw CJA.   +5 more
europepmc   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Assessment of dispersion metrics for estimating single-cell transcriptional variability. [PDF]

PLoS Comput Biol
Chen T, Boyer LA, Agarwal D.
europepmc   +1 more source

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier Damage

Advanced Science, EarlyView.
Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, Xianzhi Meng   +10 more
wiley   +1 more source

Neuromorphic computing paradigms enhance robustness through spiking neural networks. [PDF]

Nat Commun
Ding J, Yu Z, Liu JK, Huang T.
europepmc   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Study protocol to establish a prospective cohort for the study of phenotypic clusters, progression pathways, and outcomes of frailty and dependence: The CohorFES. [PDF]

PLoS One
Garcia-Giralt N, Ovejero D, Carnicero Carreño JA, Ribes A, Abizanda Soler P, Serra Rexach JA, García García FJ, Rabassa M, Rodriguez Mañas L, Sanchez Pla À, de la Fuente MEA, Osuna Del Pozo CM, Carmona I, Caballero-Mora MÁ, Mazoteras Muñoz V, Cortes Zamora EB, Avendaño Céspedes A, Agud Andreu B, Gómez Galera F, Soldado-Folgado J, Andrés Lacueva MC, Nogués X.   +21 more
europepmc   +1 more source

Information Divergences and Likelihood Ratios of Poisson Processes and Point Patterns

Lasse Leskelä
openalex   +1 more source

Deformation Driven Suction Cups: A Mechanics‐Based Approach to Wearable Electronics

Advanced Science, EarlyView.
Deformation‐driven suction cups enable robust, reversible adhesion of wearable electronics to human skin spanning wide mechanical compliance, without adhesives or tight straps. By integrating mechanics modeling, experiments, and contact mechanics theory, this work reveals how cup geometry, substrate compliance, and interfacial adhesion govern suction ...
Seola Lee, Andrew Akerson, Roham Pardakhtim, Ehsan Hajiesmaili, Kevin Rhodes, Zidong Li, Andrew Stanley, Amirhossein Amini, Daniele Piazza, Chiara Daraio, Tianshu Liu   +10 more
wiley   +1 more source

Stochastic geometry analysis of UAV-assisted networks with probabilistic UAV activation. [PDF]

Sci Rep
Selim MM.
europepmc   +1 more source