Results 101 to 110 of about 2,565,964 (296)

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

open access: yesAdvanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang   +19 more
wiley   +1 more source

BAYESIAN MULTIVARIATE POISSON REGRESSION

open access: yesCommunications in Statistics - Theory and Methods, 2001
The paper proposes a regression model for the multivariate Poisson distribution. So far inference in multivariate Poisson distributions has been prevented by the fact that computation of the probability mass function is difficult. Bayesian methods of inference are proposed which are organized around computational methods based on Gibbs sampling with ...
openaire   +2 more sources

Independent Candidates in a Parliamentary Election in India: A Poisson Regression Model [PDF]

open access: yes
The paper attempts to explain the number of independent candidates in Indian parliamentary election in the year 2004. The statistical models developed are applications and generalizations of Poisson and Negative Binomial distributions.
Bhattacharya, Kaushik
core  

Agent‐Based Simulations of Lung Tumor Evolution Suggest That Ongoing Cell Competition Drives Realistic Clonal Expansions

open access: yesAdvanced Science, EarlyView.
Computational simulations of tumor evolution are increasingly used to infer the rules underlying cancer growth, with the goal of one day recommending tailored treatments. Here we show that the properties of lung cancer sequencing data are best replicated by a model which assumes that cells compete both to proliferate and survive. ABSTRACT Computational
Helena Coggan   +5 more
wiley   +1 more source

Poisson Autoregression [PDF]

open access: yes
This paper considers geometric ergodicity and likelihood based inference for linear and nonlinear Poisson autoregressions. In the linear case the conditional mean is linked linearly to its past values as well as the observed values of the Poisson process.
Dag Tjøstheim   +2 more
core  

Latent Diffusion Process With Mechanistic Guidance For Designing Functionally Graded Metamaterials With Perfect Connectivity

open access: yesAdvanced Science, EarlyView.
A latent diffusion‐based framework is proposed for designing functionally graded metamaterials with perfect connectivity. By integrating vector‐quantized latent representations with mechanistic guidance, the framework enables accurate inverse design toward target elastic properties.
Jongbin Yu, Dosung Lee, Namjung Kim
wiley   +1 more source

Identification of Fertility Preference Determinants Using Poisson Regression

open access: yesمجله اپیدمیولوژی ایران, 2017
Background and Objectives: Changes in ideals and aspirations of childbearing are important factors in fertility behavior. Nowadays, fertility rate reduction below the replacement level and decreased childbearing ideals are the most common fertility ...
A Bagheri   +2 more
doaj  

Application of negative binomial regression in analyzing factors that influence stunting in toddlers

open access: yesDesimal
Stunting is a growth and development disorder caused by a lack of nutrition. This research aims to determine the significant factors that influence cases of stunting among toddlers in North Sumatra province in 2022. By using Negative Binomial Regression,
Allifiyani Tamimi, Ismail Husein
doaj   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

open access: yesAdvanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang   +14 more
wiley   +1 more source

A Poisson Ridge Regression Estimator [PDF]

open access: yes
The standard statistical method for analyzing count data is the Poisson regression model, which is usually estimated using maximum likelihood (ML). The ML method is very sensitive to multicollinearity. Therefore, we present a new Poisson ridge regression
Shukur, Ghazi, Månsson, Kristofer
core  

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