Results 191 to 200 of about 143,004 (295)

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

open access: yesChemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma   +13 more
wiley   +1 more source

Testing the Poisson regression model

open access: yes
A smooth test of the Poisson assumption in the Poisson regression generalised linear model is ...
Paul Rippon (21268094)   +1 more
core  

A goodness‐of‐fit test for regression models with discrete outcomes

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Regression models are often used to analyze discrete outcomes, but classical goodness‐of‐fit tests such as those based on the deviance or Pearson's statistic can be misleading or have little power in this context. To address this issue, we propose a new test, inspired by the work of Czado et al.
Lu Yang   +2 more
wiley   +1 more source

Jackknife bias‐corrected variance estimation for the generalized regression estimator

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Commonly used variance estimators for the generalized regression estimator (GREG) are based on Taylor linearization and jackknife. Traditionally, a jackknife GREG variance estimator is obtained by jackknifing GREG, which consists of computing GREG from each of several subsamples of the parent sample, and estimating the variance of the parent ...
Marius Stefan, J.N.K Rao
wiley   +1 more source

Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan   +4 more
wiley   +1 more source

CEO Duality and Corporate Social Responsibility. A Literature Review With a Focus on Country Effects

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT In recent years, many researchers have become interested in the relationship between CEO duality (where one individual serves as both CEO and board chair) and CSR outcomes. Given the varied research results, this structured literature review concentrates on the country effects of this dynamic link.
Patrick Velte
wiley   +1 more source

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