Results 41 to 50 of about 5,467 (254)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Embryonic Crude Oil Exposure Impairs Growth and Lipid Allocation in a Keystone Arctic Forage Fish

iScience, 2019
Summary: As Arctic ice recedes, future oil spills pose increasing risk to keystone species and the ecosystems they support. We show that Polar cod (Boreogadus saida), an energy-rich forage fish for marine mammals, seabirds, and other fish, are highly ...
Benjamin J. Laurel, Louise A. Copeman, Paul Iseri, Mara L. Spencer, Greg Hutchinson, Trond Nordtug, Carey E. Donald, Sonnich Meier, Sarah E. Allan, Daryle T. Boyd, Gina M. Ylitalo, James R. Cameron, Barbara L. French, Tiffany L. Linbo, Nathaniel L. Scholz, John P. Incardona   +15 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Genomic architecture and population structure of Boreogadus saida from Canadian waters

Scientific Reports
The polar cod, Boreogadus saida, is an abundant and ubiquitous forage fish and a crucial link in Arctic marine trophic dynamics. Our objective was to unravel layers of genomic structure in B.
Trevor T. Bringloe, Audrey Bourret, David Cote, Roux Marie-Julie, Jennifer Herbig, Dominique Robert, Maxime Geoffroy, Geneviève J. Parent   +7 more
doaj   +1 more source

Effect of Diazotated Sulphonated Polystyrene Films on the Calcium Oxalate Crystallization

Crystals, 2017
Pathological crystallization of calcium oxalate (CaOx) inside the urinary tract is called calculi or kidney stone (Urolithiasis). CaOx exhibits three crystalline types in nature: CaOx monohydrate COM, dihydrate COD and trihydrate COT.
Patricio Vásquez-Quitral, Javier Toledo Arana, Maria Cristina Miras, Diego Fernando Acevedo, Cesar Alfredo Barbero, Andrónico Neira-Carrillo   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The thick-billed murre (Uria lomvia) in Northwest Greenland (Avanersuaq) relies on Arctic cod (Boreogadus saida) in a changing climate

Arctic Science
Considering seabirds as indicators of environmental change, we compared thick-billed murre (Uria lomvia (Linnaeus, 1758)) adult and chick diet in the North Water polynya region, NW Greenland, during 1997 and 2023.
Knud Falk, Flemming Ravn Merkel, Myrthe Bergsma, Kasper Lambert Johansen, Kaj Kampp, Aili Lage Labansen, Anders Mosbech, Maasannguaq Oshima, Caroline Bouchard   +8 more
doaj   +1 more source

The Record-Warm Barents Sea and 0-Group Fish Response to Abnormal Conditions

Frontiers in Marine Science, 2020
The Barents Sea is a nursery area for many commercially and ecologically important fish stocks, and this whole region is presently subject to rapid climatic change from a cold period in the 1980s to a record warm period in the latest decade, with a peak ...
Elena Eriksen, Espen Bagøien, Espen Strand, Raul Primicerio, Raul Primicerio, Tatiana Prokhorova, Alexander Trofimov, Irina Prokopchuk   +7 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source