Results 81 to 90 of about 84,554 (258)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Rateless Polar-Spinal Coding Scheme With Enhanced Information Unequal Error Protection

open access: yesIEEE Access, 2019
In this paper, a rateless coding scheme with enhanced unequal error protection (UEP) property is proposed by concatenating the systematic polar code (SPC) and spinal code, where SPC is used as the outer code and spinal code is the inner code.
Hao Liang   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Low-Complexity CRC Aided Joint Iterative Detection and SCL Decoding Receiver of Polar Coded SCMA System

open access: yesIEEE Access, 2020
As the fifth-generation (5G) wireless networks' key technology, the joint design of SCMA and polar code is concerned by the future communication system. In this paper, a CRC aided joint iterative detection and successive cancellation list (SCL) decoding (
Xi Wu, Yafeng Wang, Chuanfeng Li
doaj   +1 more source

A practical approach to polar codes [PDF]

open access: yes2011 IEEE International Symposium on Information Theory Proceedings, 2011
In this paper, we study polar codes from a practical point of view. In particular, we study concatenated polar codes and rate-compatible polar codes. First, we propose a concatenation scheme including polar codes and Low-Density Parity-Check (LDPC) codes.
Ali Eslami, Hossein Pishro-Nik
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Serially Concatenated Polar Codes

open access: yesIEEE Access, 2018
Simulation results show that the performance of polar codes is improved vastly by using polar codes as inner codes in serially concatenated coding schemes.
Erdal Arikan
doaj   +1 more source

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