Results 71 to 80 of about 1,969,454 (306)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Comments to a polar bear population model

open access: yes, 1985
Larsen, T. & Ugland, K. I. (Polar Research 2 n.s., 117-118) note correctly that a Leslie matrix model treats cubs and females as independent units which is not the case for polar bears.
Øritsland, Nils Are
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Convolutional Polar Codes

open access: yesCoRR, 2017
Arikan's Polar codes attracted much attention as the first efficiently decodable and capacity achieving codes. Furthermore, Polar codes exhibit an exponentially decreasing block error probability with an asymptotic error exponent upper bounded by 1/2. Since their discovery, many attempts have been made to improve the error exponent and the finite block-
Andrew James Ferris   +2 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

List decoding of polar codes [PDF]

open access: yes2011 IEEE International Symposium on Information Theory Proceedings, 2011
We describe a successive-cancellation \emph{list} decoder for polar codes, which is a generalization of the classic successive-cancellation decoder of Arıkan. In the proposed list decoder, up to $L$ decoding paths are considered concurrently at each decoding stage. Then, a single codeword is selected from the list as output. If the most likely codeword
Ido Tal, Alexander Vardy
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Trichinella sp. in polar bears from Svalbard, in relation to hide length and age

open access: yes, 2010
Diaphragm and masseter muscles from 376 polar bears ((irsur maririmus), 252 ringed seals (Phocn hispida), 84 bearded seals (Erignarhus barbarus), and 77 arctic foxes (Alopex lagopus) from Svalbard were examined for Trichinelln.
Larsen, Thor, Kjos-Hanssen, Bjørn
core   +1 more source

Design and Optimization of Joint Iterative Detection and Decoding Receiver for Uplink Polar Coded SCMA System

open access: yesIEEE Access, 2018
SCMA and polar coding are possible candidates for 5G systems. In this paper, we firstly propose the joint iterative detection and decoding (JIDD) receiver for the uplink polar coded sparse code multiple access (PC-SCMA) system.
Zhipeng Pan   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

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