Results 91 to 100 of about 1,547,748 (299)

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Preliminary Estimation and Validation of Polar Motion Excitation from Different Types of the GRACE and GRACE Follow-On Missions Data

Remote Sensing, 2020
The Gravity Recovery and Climate Experiment (GRACE) mission has provided global observations of temporal variations in the gravity field resulting from mass redistribution at the surface and within the Earth for the period 2002–2017.
Justyna Śliwińska, Małgorzata Wińska, Jolanta Nastula   +2 more
doaj   +1 more source

Review of LASHIPA: History of Large Scale Resource Exploitation in Polar Areas, edited by Louwrens Hacquebord

, 2013
This collection of papers reflects the results of two separate but related research projects: the International Polar Year (IPY) project History of Large Scale Resource Exploitation in Polar Areas (LASHIPA) and a European Science Foundation Collaborative
Capelotti, P. J.
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Reassessment of electromagnetic core-mantle coupling and its implications to the Earth's decadal polar motion

Geodesy and Geodynamics, 2019
The observed Earth's polar motion on decadal time scales has long been conjectured to be excited by the exchange of equatorial angular momentum between the solid mantle and the fluid outer core, via the mechanism of electromagnetic (EM) core-mantle ...
Weijia Kuang, Benjamin F. Chao, Jianli Chen   +2 more
doaj   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

Improving the Accuracy of Polar Motion Prediction by Combining Least Squares and the iTransformer Model

Earth and Space Science
Polar motion prediction is an important means to study the dynamics of Earth's rotation and detect the internal structure of the Earth. This paper proposes an LS + iTransformer method that combines the least squares (LS) method with the iTransformer deep
Huizhong Zhu, Yi Yang, Chunhua Jiang, Wenfeng Nie, Zhenyu Luo, Zhangzhen Sun   +5 more
doaj   +1 more source

Review of 100 facts: polar lands; 365 penguins; Amazing Arctic & Antarctic projects you can build yourself; Apun: the Arctic snow; Matthew Henson: the quest for the North Pole; Polar bears in danger; Polar regions; Race to the South Poleetc.

, 2010
The polar regions have captured the world’s attention, and children’s book authors and publishers are no exception. These dozen titles are just a sample of the bucketload of polar-themed children’s books that have been published during the last couple of
Goldman, Helle
core   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source