Results 61 to 70 of about 76,940 (295)

Geomagnetic Polarity Timescales and Reversal Frequency Regimes [PDF]

, 2004
An analysis of geomagnetic reversal history is made for the most reliable polarity timescales covering the last 160 Myr. The timescale of Cande and Kent [1995] (CK95) is the optimum representation of Cenozoic and Late Cretaceous polarity history, and the
Kent, Dennis V., Lowrie, William
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Predicting the Timing of the Solar Cycle 25 Polar Field Reversal

The Astrophysical Journal Letters
The process of the Sun’s polar field cancellation reversal commences with the emergence of new cycle Hale’s polarity active regions. Once the Sun undergoes polarity reversal, typically occurring near the peak of solar activity, it begins the process of ...
Bibhuti Kumar Jha, Lisa A. Upton
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

POLARIZATION REVERSAL IN DEVELOPING COUNTRIES

Papers in Regional Science, 1980
POLARIZATION REVERSAL AND THE SPATIAL DEVELOPMENT PROCESS In a recent fugitive, though reasonably well-circulated paper [21] I coined the term polarization reversal (hereafter PR). Although this clumsy inelegant phrase is merely a new name for a well-known, if underresearched, spatial phenomenon, it seems to have fired the imagination of some observers
openaire   +1 more source

Polar cap magnetic field reversals during solar grand minima: could pores play a role?

, 2015
We study the magnetic flux carried by pores located outside active regions with sunspots and investigate their possible contribution to the reversal of the global magnetic field of the Sun.
Brun, A. S., Jouve, L., Roudier, Th., Svanda, M.   +3 more
core   +4 more sources

Solar magnetic field reversal as seen at Ulysses [PDF]

, 2003
The rapid motion of the Ulysses spacecraft from high southern to high northern latitudes in 2000–2001 provided an excellent opportunity to make inferences regarding the solar magnetic dipole's behaviour around solar maximum.
Balogh, A., Jones, G.H., Smith, E.J.
core   +1 more source

Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells

eLife, 2017
The asymmetric location of stereociliary bundle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure.
Tao Jiang, Katie Kindt, Doris K Wu
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source