Results 91 to 100 of about 19,917 (275)

Coherent terabit communications with microresonator Kerr frequency combs

, 2014
Optical frequency combs enable coherent data transmission on hundreds of wavelength channels and have the potential to revolutionize terabit communications.
Brasch, Victor, Freude, Wolfgang, Hartinger, Klaus, Herr, Tobias, Hillerkuss, David, Holzwarth, Ronald, Kippenberg, Tobias J., Koos, Christian, Lauermann, Matthias, Leuthold, Juerg, Li, Jingshi, Pfeifle, Joerg, Schindler, Philipp, Schmogrow, Rene, Wegner, Daniel, Weimann, Claudius, Yu, Yimin   +16 more
core   +2 more sources

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

W-Band PDM-QPSK Vector Signal Generation by MZM-Based Photonic Frequency Octupling and Precoding

IEEE Photonics Journal, 2015
We experimentally demonstrate polarization-division-multiplexing quadrature-phase-shift-keying (PDM-QPSK) modulated vector signal generation at the W-band, adopting Mach-Zehnder-modulator-based (MZM-based) photonic frequency octupling and phase precoding
Xinying Li, Jianjun Yu, Jiangnan Xiao, Nan Chi, Yuming Xu   +4 more
doaj   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Study of Free‐Space Optical Quantum Network: Review and Prospectives

Advanced Science, EarlyView.
Free from the constraints of fiber connections, free‐space quantum network enables longer and more flexible quantum network connections. This review summarizes and comparatively analyzes free‐space quantum network experiments based on ground stations, satellites, and mobile platforms.
Hua‐Ying Liu, Zhenda Xie, Shining Zhu
wiley   +1 more source

Cryoablation Activates the cGAS–STING‐CXCL10 Axis in Macrophages to Enhance Anti‐Tumor Immunity in NSCLC

Advanced Science, EarlyView.
Tumor dsDNA released by cryoablation is taken up by macrophages, activating the cGAS‐STING signaling pathway. This leads to an expansion of the CXCL10+ macrophage pool and increased secretion of CXCL10, which in turn recruits CXCR3+ T cells from draining lymph nodes into the tumor microenvironment to exert anti‐tumor effects.
Xinxin Zhi, Zhengcao Xing, Libo Luo, Jiale Wang, Xinyu Liu, Jia Yu, Jizhong Yin, Bin Chen, Yiwei Liu, Hui Sun, Guanghui Gao, Lei Wang, Xiaoxia Chen, Fei Li, Hu Ma, Lin Wang, Shuo Yang, Shengxiang Ren   +17 more
wiley   +1 more source

Field Test of Classical Symmetric Encryption with Continuous Variable Quantum Key Distribution

, 2012
We report on the design and performance of a point-to-point classical symmetric encryption link with fast key renewal provided by a Continuous Variable Quantum Key Distribution (CVQKD) system. Our system was operational and able to encrypt point-to-point
Anthony Leverrier, Dinh Xuan, Eleni Diamanti, Elser, Eraerds, Fossier, García-Patrón, Grosshans, Grosshans, Heim, Häseler, Jouguet, Lance, Leverrier, Leverrier, Lodewyck, Lodewyck, Lorenz, Lorenz, Navascués, Paul Jouguet, Peev, Philippe Grangier, Philippe Pache, Philippe Painchault, Qi, Qi, Romain Alléaume, Rosa Tualle-Brouri, Sasaki, Scarani, Shen, Simon Fossier, Stucki, Symul, Sébastien Kunz-Jacques, Thierry Debuisschert, Wegman, Wegman   +38 more
core   +3 more sources

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Multi-user distribution of polarization entangled photon pairs

, 2015
We experimentally demonstrate multi-user distribution of polarization entanglement using commercial tele- com wavelength division demultiplexers. The entangled photon pairs are generated from a broadband source based on spontaneous parametric down ...
Diamanti, E., Ghalbouni, J., Orieux, A., Trapateau, J., Zaquine, I.   +4 more
core   +3 more sources

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source