Results 211 to 220 of about 19,795 (292)

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng   +7 more
wiley   +1 more source

Multifunctional Programmable Transmissive Metasurface with Phase and Amplitude Manipulation Capability

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
This work provides a multifunctional programmable transmissive metasurface with phase and amplitude manipulation capability in the sub‐6G band. By applying different coding strategies, the proposed metasurface can realize vortex beam generation, holographic imaging under phase coding mode, and multi‐beam forming in phase‐amplitude joint coding mode ...
Hao Tian Shi   +8 more
wiley   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

open access: yesAdvanced Science, Volume 13, Issue 16, 18 March 2026.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang   +10 more
wiley   +1 more source

Quantum entanglement network enabled by a state-multiplexing quantum light source. [PDF]

open access: yesLight Sci Appl
Fan YR   +11 more
europepmc   +1 more source

Biomimetic Iridium‐Based Photothermal Nanozyme to Trigger Ferroptosis and Pyroptosis and Activate the cGAS‐STING Pathway for Improved Tumor Immunotherapy

open access: yesAdvanced Science, Volume 13, Issue 16, 18 March 2026.
This study develops an iridium‐based nanozyme (IIN@M) with superior enzyme‐like activity and photothermal performance. It disrupts intracellular redox balance by generating reactive oxygen species and depleting glutathione, which synergistically induces ferroptosis, pyroptosis, and immunogenic cell death.
Lijun Ding   +7 more
wiley   +1 more source

Nonlinear optical vector processing using linear silicon photonic circuits for 50 Gb/s memory and string similarity functions. [PDF]

open access: yesNat Commun
Moschos T   +11 more
europepmc   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

open access: yesAdvanced Science, Volume 13, Issue 17, 23 March 2026.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang   +14 more
wiley   +1 more source

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