Results 201 to 210 of about 19,948 (281)

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Joint communication and sensing with structured beams carrying orbital angular momentum. [PDF]

Nat Commun
Shen R, Ghasempour Y.
europepmc   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Metaoptics merging computational optics and optical computing toward intelligent visual perception. [PDF]

Sci Adv
Hu Y, Chi H, Duan H.
europepmc   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

High-speed all-optical neural networks empowered spatiotemporal mode multiplexing. [PDF]

Light Sci Appl
Feng F, Li X, Zhang Z, Gan J, Yuan X.
europepmc   +1 more source

Large‐Aperture Polarization‐Independent Broadband Achromatic All‐Dielectric Metalens for Terahertz Focusing

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A large‐aperture, high focusing efficiency and polarization‐independent THz single‐layer achromatic metalens is reported via discrete multi‐wavelength achromatic design and global optimization algorithm. The fabricated metalens exhibits a largest diameter of 2.21 cm, excellent achromatic performance, extremely high average focusing efficiency (> 46 ...
Xiaoqiang Jiang, Xu Chen, Zechuan Bin, Fu Tang, Min Hu, Manman Li, Wenhui Fan, Baoli Yao   +7 more
wiley   +1 more source

On-chip nonlocal metasurface for color router: conquering efficiency-loss from spatial-multiplexing. [PDF]

Light Sci Appl
Shi Y, Wan S, Wang Z, Rao R, Li Z.
europepmc   +1 more source

Molecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole‐Blood RNA Transcriptome

Arthritis &Rheumatology, Volume 78, Issue 5, Page 1124-1133, May 2026.
Objective Antiphospholipid syndrome (APS) is a thromboinflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)–positive patients using whole‐blood transcriptomics.
Amala Ambati, Feiyang Ma, Katarina Kmetova, Sherwin Navaz, Claire K. Hoy, Cyrus Sarosh, Ajay Tambralli, Erika Navarro‐Mendoza, Johann E. Gudjonsson, J. Michelle Kahlenberg, Jacqueline A. Madison, Alí Duarte‐García, Jason S. Knight, Yu Zuo   +13 more
wiley   +1 more source

Coherent optical interconnects using Fermat number transform and hollow core fibre. [PDF]

Commun Eng
Chen S, Liu Z, Zhao C, Zhang M, Li P, Zhang L, Luo J, Hu Z, Chen C, Hua X, Liao X, Zhao Z, Tang M.   +12 more
europepmc   +1 more source