Results 221 to 230 of about 5,667,394 (345)

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Institutional and policy networks in disaster management in the Horn of Africa: insights from Kenya. [PDF]

Disasters
Mohamed T.
europepmc   +1 more source

Clickable Microgel Inks Enable Spatioselective, Multi‐Stimuli Programmable Assembly of Materials

Advanced Science, EarlyView.
Clickable microgel inks enable direct ink writing of hydrogel architectures with intrinsic spatioselective and programmable multi‐responsiveness. By combining pH‐responsive and temperature‐responsive microgel building blocks through Diels‐Alder interparticle crosslinking, the assemblies exhibit controllable swelling and shape changes.
Junho Moon, Frank Gardea, Madeline A. Morales, Svetlana Sukhishvili   +3 more
wiley   +1 more source

Factors Influencing the Implementation of a Disability Package for Children with Developmental Disabilities: A Policy Analysis. [PDF]

Acta Med Philipp
Martinez PGV, Sy MP.
europepmc   +1 more source

Off-Policy Natural Actor-Critic

Off-Policy Natural Actor-Critic
Recently-developed Natural Actor-Critic (NAC) [1] [2], which employs natural policy gradient learning for the actor and LSTD-Q(λ) for the critic, has provided a good model-free reinforcement learning scheme applicable to high-dimensional systems.
openaire  

Analog Signal Summation for Reinforcement Learning via Simultaneous Light–Voltage Modulation in a Synaptic Device

Advanced Science, EarlyView.
To overcome limitations of conventional AI hardware, a light‐voltage dual‐modulating synaptic (LVDS) transistor using an IGZO/InAs quantum dot hybrid structure is proposed. LVDS transistor enables analog summation for Dueling Deep Q‐Networks by independently modulating memory via optical and electrical stimuli.
Dong Gue Roe, Sungjoon Cheon, Seongil Im, Sinil Choi, Meeree Kim, Subeen Kim, Youngjae Yoo, Jeong Won Kim, Hyunsu Ju, Sohee Jeong, Jeong Ho Cho   +10 more
wiley   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Navigating the Map of Environmental-policy Narratives and its Influence within the Conservation Network of the Colombian-Peruvian Amazon. [PDF]

Environ Manage
González-Rodríguez CE, Buitrago-Bermúdez O, Gonzalez C, Castillo-Rivera JM, Le Coq JF.   +4 more
europepmc   +1 more source

Enhanced Photocatalytic CO2 Reduction Performance by External Electric Field‐Driven Charge Separation on Interdigitated Micro‐Spacing Structure

Advanced Science, EarlyView.
An external electric field‐enhanced photocatalytic system is developed using interdigitated electrodes with 100 µm spacing to overcome the liquid‐phase limitations of traditional PEC. The induced high‐intensity electric field effectively drives the directional migration of charge carriers under low voltage. This strategy significantly suppresses charge
Xidan Tang, Zhenyu Yu, Jie Liang, Xiaoguang Wang, Qin Shi, Honghui Pan, Xixiang Liu, Pengyi Tang   +7 more
wiley   +1 more source