Results 241 to 250 of about 22,135,772 (359)
The association between healthy walking and COVID-19 symptom severity: A cross-sectional study on the first peak following China's prevention policy change. [PDF]
Xia W +10 more
europepmc +1 more source
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen +19 more
wiley +1 more source
Diabetes Management: A Case Study to Drive National Policy Change in Primary Care Settings. [PDF]
Bannuru RR +3 more
europepmc +1 more source
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang +10 more
wiley +1 more source
Assessing racial disparities in heart transplant allocations post-2018 policy change. [PDF]
Malkani K, Zhang R, Kini V.
europepmc +1 more source
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu +8 more
wiley +1 more source
Impact of lung allocation policy change on Hispanic lung transplant outcomes: Addressing disparities and improving access. [PDF]
Klipsch E +10 more
europepmc +1 more source

