Results 41 to 50 of about 23,854,368 (360)

Policy Preferences and Policy Change: Dynamic Responsiveness in the American States, 1936–2014

open access: yesAmerican Political Science Review, 2017
Using eight decades of data, we examine the magnitude, mechanisms, and moderators of dynamic responsiveness in the American states. We show that on both economic and (especially) social issues, the liberalism of state publics predicts future change in ...
Devin Caughey, C. Warshaw
semanticscholar   +1 more source

Treatment Decision‐Making Roles and Preferences Among Adolescents and Young Adults With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Decision‐making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and socioeconomically diverse group of AYAs and their parents.
Amanda M. Gutierrez   +14 more
wiley   +1 more source

Climate Change Policy, and Policy Change in China [PDF]

open access: yes, 2008
Solving the climate change problem by limiting global greenhouse gas (GHG) emissions will necessitate action by the world’s two largest emitters, the United States and China. Neither has so far committed to quantitative emissions limits.
Wiener, Jonathan B.
core   +1 more source

Accounting for health in climate change policies: a case study of Fiji [PDF]

open access: yes, 2016
BACKGROUND Climate change is expected to affect the health of most populations in the coming decades, having the greatest impact on the poorest and most disadvantaged people in the world.
Bowen, Kathryn, Morrow, Georgina
core   +1 more source

Regional financial performance evaluation in the Indonesian fiscal decentralization era

open access: yesJurnal Perspektif Pembiayaan dan Pembangunan Daerah, 2018
Under the decentralization policy, regions have the rights and obligations in arranging of themselves. Then many studies showed positive and negative impacts of fiscal decentralization in Indonesia.
Joko Tri Haryanto
doaj   +1 more source

Evaluation of the Utility of Baseline Echocardiogram in Patients With Standard Risk Precursor B‐Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
Abstract Background A routine baseline echocardiogram is often obtained prior to anthracycline administration in children with cancer. The utility of baseline echocardiogram is unclear in patients with standard risk B‐cell acute lymphoblastic leukemia (SR B‐ALL) as their anthracycline cumulative dose is low.
Ziyad Alrajhi   +4 more
wiley   +1 more source

Assessing The Current Indonesia’s Electricity Market Arrangements and The Opportunities to Reform

open access: yesInternational Journal of Renewable Energy Development, 2015
Existing subsidy arrangements and institutional settings in the Indonesian electricity sector distort investment decisions and lead to higher cost. Electricity supply is characterized by natural monopoly characteristics, requiring different management by
Dhani Setyawan
doaj   +1 more source

Shaping Policy Change in Population Health: Policy Entrepreneurs, Ideas, and Institutions

open access: yesInternational Journal of Health Policy and Management, 2018
Political realities and institutional structures are often ignored when gathering evidence to influence population health policies. If these policies are to be successful, social science literature on policy change should be integrated into the ...
D. Béland, T. Katapally
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

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