Results 211 to 220 of about 533,555 (259)

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Large Language Model‐Informed Dual‐Track AI Framework for the Synergistic Design of Crack‐Free and High‐Strength Superalloys

Advanced Science, EarlyView.
This paper illustrates a knowledge‐augmented dual‐track AI framework for advanced superalloy design. First, Large Language Models translate metallurgical heuristics into explicit rules to rapidly prune a vast compositional search space. Subsequently, LLM‐distilled priors safely guide a reinforcement learning agent during autonomous process optimization,
Jian Yao, Junkang Wu, Jie Su, Fuzhu Wang, Zi Wang, Li Wang, Liming Tan, Lan Huang, Feng Liu, Yong Liu   +9 more
wiley   +1 more source

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Evaluation policy in the Netherlands

New Directions for Evaluation, 2009
AbstractThis chapter discusses the development of evaluation policy in the Netherlands. It distinguishes between several periods: the 1970s and before, when there was little or no evaluation, much less evaluation policy; the late 1970s and 1980s, when evaluation increased but there was still little formal policy; the 1990s, when the government began to
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Policy Evaluation and Policy Examination

2020
The chapter focuses on post-implementation evaluation and examination of policy, determining its effectiveness and efficiency and determining whether new policy or modifications to existing policy are necessary. This evaluation assesses the impact of policy and the tools used to implement it.
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Policy Theory and Policy Evaluation

1990
An innovative contribution to the literature of political science, this five-part volume explores the four basic theoretical issues in public policy analysis: conceptual theory, theory of knowing, casual theory, and normative analysis. A fifth section addresses future aspects of policy theory.
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Policy Evaluations

1999
AbstractSpillover explanations of the progress of European integration are examined within the context of the attitudes of political elites. In particular, the linkage between perceptions of past success and policy evaluation and parliamentarians’ views on the future of integration is evaluated.
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Evaluation and Policy Evaluation

2023
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