Results 41 to 50 of about 1,540,946 (305)

Science for transformative change: the IPCC, boundary work and the making of useable knowledge

Frontiers in Climate
While there has been much discussion about what kind of expertise the IPCC needs to develop to (better) guide climate policy, little has been said about how the experts themselves assess the challenges of making science policy-relevant. The paper aims to
Rolf Lidskog
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Preliminary testing of the reliability and feasibility of SAGE: a system to measure and score engagement with and use of research in health policies and programs

Implementation Science, 2017
Background Few measures of research use in health policymaking are available, and the reliability of such measures has yet to be evaluated. A new measure called the Staff Assessment of Engagement with Evidence (SAGE) incorporates an interview that ...
Steve R. Makkar, Anna Williamson, Catherine D’Este, Sally Redman   +3 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Trust, conspiracy theory, and COVID-19 vaccination intention in Kazakhstan

Cogent Social Sciences
This study examined the association between trust, conspiracy thinking, and COVID-19 vaccination intention in Kazakhstan using representative cross-sectional data from 1,035 respondents.
Nurzhan Aidossov, Serzhan Nazarbek, Riccardo Pelizzo, Magashi Joseph Ntegwa, Kuanysh A. Yergaliyev, Gulsara Junusbekova   +5 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Why Do Financial Market Experts Misperceive Future Monetary Policy Decisions? [PDF]

This paper investigates why financial market experts misperceive the interest rate policy of the European Central Bank (ECB). Assuming a Taylor-rule-type reaction function of the ECB, we use qualitative survey data on expectations about the future ...
Dieter Nautz, Sandra Schmidt
core   +3 more sources

Health Care Opinion Leaders' Views on Health Care Delivery System Reform [PDF]

, 2008
Presents findings of a survey of experts on reforming delivery systems -- organized delivery systems, patient-centered medical homes, and retail clinics -- and recommended policy strategies, such as improving the primary care ...
Anthony Shih, Karen Davis, Katherine K. Shea   +2 more
core  

Does Greek Conservation Policy Effectively Protect the Cultural Landscapes? A Critical Examination of Policy’s Efficiency in Traditional Greek Settlements [PDF]

, 2014
The first part focuses on the legislative framework, providing a critical examination regarding the way that cultural landscape is approached. The second part discusses the effects of this policy on a group of traditional settlements in central Greece ...
Katapidi, Ioanna
core   +2 more sources