Results 251 to 260 of about 6,773,965 (316)

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

Exploring the antecedents of tourist satisfaction: A big data analysis of ice and snow tourism destinations. [PDF]

PLoS One
Wang S, Chen S, Guan Q.
europepmc   +1 more source

China's Low‐Carbon Energy Transition Over the Past Two Decades: Experiences and Implications

Advanced Science, EarlyView.
China's low‐carbon energy transition features a brief decline and subsequent rebound in coal consumption, alongside the rapid expansion of renewable energy. This study develops a stage‐based analytical framework to explain this evolution from the perspectives of economic development, energy security, and environmental sustainability, revealing how ...
Yu Liu, Zhiyu Tian, Zhengxian Zhang, Xinbei Li   +3 more
wiley   +1 more source

Households under pressure: a systems framework for modeling the "watch" famine archetype. [PDF]

J Public Health Policy
Thorn AM.
europepmc   +1 more source

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Barriers to Electronic Prescription Circulation Under Employee Medical Insurance Outpatient Coordination: Evidence from a Pilot City in China. [PDF]

Risk Manag Healthc Policy
Peng Y, Zheng Y, Wang C, Yang W, Li Q, Xiao Z, Yang J.   +6 more
europepmc   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Multi-Model Ensembles in Ecosystem Modeling: Challenges and Best Practices for Decision-Making. [PDF]

Glob Chang Biol
Guan K, Qin R, Ma Z, Zhao L, Liu L, Wang S, Keenan TF, Jia M, Sihi D, Potash E, Asseng S, Tang J, Xu X, Boomer K, Peng B, Jin Z, Hoffman FM, Ogle S, Coppess J, Khanna M, Whitcraft A, Runkle BRK.   +21 more
europepmc   +1 more source

Brucellosis in healthcare settings: research advances in nosocomial infection prevention and control. [PDF]

Front Public Health
Du X, Li L, Wang G.
europepmc   +1 more source

In response: do-not-resuscitate designation as a hemovigilance strategy for Rh(D)-negative inventory stewardship. [PDF]

Transfusion
Li X, Xiao Z, Jin C.
europepmc   +1 more source