Results 31 to 40 of about 1,405,758 (306)

Policy-making under uncertainty [PDF]

Behavioural Public Policy, 2018
AbstractThe problem with decision-making in an institutional setting is that it is often more important for one's reputation and job security to appear to be logical than it is to be truly effective. Indeed, a far lower burden of proof is applied to ideas and suggestions that accord with simple economic axioms than to those that are oblique ...
openaire   +1 more source

Beyond precautionary principle: policy-making under uncertainty and complexity

Policy Design and Practice
The precautionary principle is a widely recognized approach in policy-making across various fields, emphasizing preventive action in situations of uncertain potential harm.
Xun Wu, Liang Ma, Donald Low, Shubham Sharma, Gleb Papyshev   +4 more
doaj   +1 more source

A typology of authoritarian social policy design under uncertainty

Policy Design and Practice
This study examines how authoritarian regimes design social policies during crises, emphasizing how distinct forms of uncertainty shape policy instruments and governance strategies. Introducing a typology of uncertainty; relational, epistemic, legitimacy-
Anis Ben Brik
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Agricultural investment under climate policy uncertainty: evidence from China

Frontiers in Sustainable Food Systems
This study investigates the dynamic, bidirectional relationship between climate policy uncertainty (CPU) and agricultural investment (AGRI) in China.
Zizhe Du, Chao Chen, Yuyin Zhao
doaj   +1 more source

Do Geopolitical Tensions and Economic Policy Uncertainties Reorient Mineral Imports in the USA? A Fat-Tailed Data Analysis Using Novel Quantile Approaches

Mathematics, 2022
Mineral resources are essential raw materials to generate electricity, fuel vehicles, and heat homes and workplaces. Besides, the global agenda of clean energy deployment, including solar photovoltaics (PV), wind turbines, electric vehicles (EV), and ...
Md. Monirul Islam, Kazi Sohag, Faheem ur Rehman   +2 more
doaj   +1 more source

Policy Competition, Imitation and Coordination Under Uncertainty

SSRN Electronic Journal, 2022
The paper analyzes under what circumstances policymakers experiment with policies with uncertain outcomes, when they prefer to imitate policies initiated in other countries, and when they prefer to coordinate policies internationally. Policymakers have private costs of active policies and compete internationally in a yardstick competition which gives ...
openaire   +4 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Coordinating power sector climate transitions under policy uncertainty

Nature Communications
Effective climate policy requires coordination among political jurisdictions with large differences in institutional make-up and interest group structures.
Fikri Kucuksayacigil, Zhenhua Zhang, Michael R. Davidson   +2 more
doaj   +1 more source

Analysis of Climate Policy Targets under Uncertainty [PDF]

, 2009
and PDF report are also available on the MIT Joint Program on the Science and Policy of Global Change website (http://globalchange.mit.edu/).Although policymaking in response to the climate change is essentially a challenge of risk management, most ...
Forest, Chris Eliot, Jacoby, Henry D., Kicklighter, David W., Melillo, Jerry M., Paltsev, Sergey, Prinn, Ronald G., Reilly, John M., Sarofim, Marcus C., Schlosser, C. Adam, Sokolov, Andrei P., Wang, Chien, Webster, Mort D.   +11 more
core   +1 more source