Results 11 to 20 of about 232 (129)

Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis. [PDF]

Adv Sci (Weinh), 2022
A comprehensive study to decipher hepatic steatosis (HS) by generating multiomics data including oral and gut metagenomics as well as plasma metabolomics and inflammatory proteomics data in a well‐characterized metabolic dysfunction‐associated fatty liver disease (MAFLD) cohort. Abstract Metabolic dysfunction‐associated fatty liver disease (MAFLD) is a
Zeybel M, Arif M, Li X, Altay O, Yang H, Shi M, Akyildiz M, Saglam B, Gonenli MG, Yigit B, Ulukan B, Ural D, Shoaie S, Turkez H, Nielsen J, Zhang C, Uhlén M, Borén J, Mardinoglu A.   +18 more
europepmc   +2 more sources

Evolution of fungal tuberculosis necrotizing toxin (TNT) domain-containing enzymes reveals divergent adaptations to enhance NAD cleavage. [PDF]

Protein Sci
Abstract Tuberculosis necrotizing toxin (TNT) is a protein domain discovered on the outer membrane of Mycobacterium tuberculosis (Mtb), and the fungal pathogen Aspergillus fumigatus. TNT domains have pure NAD(P) hydrolytic activity, setting them apart from other NAD‐cleaving domains such as ADP‐ribosyl cyclase and Toll/interleukin‐1 receptor homology ...
Ferrario E, Kallio JP, Emdadi M, Strømland Ø, Rack JGM, Ziegler M.   +5 more
europepmc   +2 more sources

Ligand binding Pro-miscuity of acylpeptide hydrolase, structural analysis of a detoxifying serine hydrolase. [PDF]

Protein Sci
Abstract Acylpeptide hydrolase (APEH) or acylaminoacyl‐peptidase (AAP) is a serine hydrolase that regulates protein metabolism. It can also bind to and process unusual substrates, acting as a detoxifier. To better understand its promiscuous specificity, we determined the cryo‐EM structures of mammalian APEH complexed with classical serine protease ...
Kiss-Szemán AJ, Takács L, Jákli I, Bánóczi Z, Hosogi N, Traore DAK, Harmat V, Perczel A, Menyhárd DK.   +8 more
europepmc   +2 more sources

Multiscale Design of Dental Restorative Materials: Mechanistic Foundations, Technological Innovations, and Clinical Translation. [PDF]

Adv Sci (Weinh)
From conventional ceramics to bioinspired smart composites, this review charts the evolution of dental restorative biomaterials. Integrating materials innovation, advanced manufacturing technologies, and bioinspired strategies, it presents a roadmap for developing functional, clinically translatable restorations that combine durability, adaptability ...
Li B, Ai R, Chen X, Wang Y, Pan C, Song S, Yang C, Zhou Y, Zhang Z, Liu X, Liu X, Yao L, Zhang Q, Gu W, Zhang R.   +14 more
europepmc   +2 more sources

Metamorphic Malware and Obfuscation: A Survey of Techniques, Variants, and Generation Kits

Security and Communication Networks, Volume 2023, Issue 1, 2023., 2023
The competing landscape between malware authors and security analysts is an ever‐changing battlefield over who can innovate over the other. While security analysts are constantly updating their signatures of known malware, malware variants are changing their signature each time they infect a new host, leading to an endless game of cat and mouse.
Kenneth Brezinski, Ken Ferens, Konstantinos Rantos   +2 more
wiley   +1 more source

High‐Efficiency Luminescent Solar Concentrators Based on Antifogging and Frost‐Resisting Fluorescent Polymers: Adding Multiple Functions for Sustained Performance

Advanced Materials Interfaces, Volume 9, Issue 14, May 13, 2022., 2022
The first demonstration of an antifogging/frost‐resisting thin‐film luminescent solar concentrator based on a multifunctional, highly transparent, photostable, fluorescent methacrylic polymer as host matrix is presented in this work. Excellent device efficiency is demonstrated by tailoring polymer composition to allow for an effective donor–acceptor ...
Francesca Corsini, Chiara Maria Rizzini, Chiara Botta, Stefano Turri, Gianmarco Griffini   +4 more
wiley   +1 more source

iPSC-Derived Liver Organoids as a Tool to Study Medium Chain Acyl-CoA Dehydrogenase Deficiency. [PDF]

J Inherit Metab Dis
ABSTRACT Medium chain acyl‐CoA dehydrogenase deficiency (MCADD) is an inherited metabolic disease, characterized by biallelic variants in the ACADM gene. Interestingly, even with the same genotype, patients often present with very heterogeneous symptoms, ranging from fully asymptomatic to life‐threatening hypoketotic hypoglycemia.
Kiyuna LA, Horcas-Nieto JM, Odendaal C, Langelaar-Makkinje M, Gerding A, Broekhuis MJC, Bonanini F, Singh M, Kurek D, Harms AC, Hankemeier T, Foijer F, Derks TGJ, Bakker BM.   +13 more
europepmc   +2 more sources

Combined Metabolic Activators Accelerates Recovery in Mild‐to‐Moderate COVID‐19

Advanced Science, Volume 8, Issue 17, September 8, 2021., 2021
Open‐label phase‐2 and double‐blinded phase‐3 clinical trials show that administration of CMA accelerates the recovery of ambulatory COVID‐19 patients. By integrating clinical data with plasma metabolomics and inflammatory proteomics, it is shown that CMA improves immune response and regulates antioxidant, amino acid, and lipid metabolism.
Ozlem Altay, Muhammad Arif, Xiangyu Li, Hong Yang, Mehtap Aydın, Gizem Alkurt, Woonghee Kim, Dogukan Akyol, Cheng Zhang, Gizem Dinler‐Doganay, Hasan Turkez, Saeed Shoaie, Jens Nielsen, Jan Borén, Oktay Olmuscelik, Levent Doganay, Mathias Uhlén, Adil Mardinoglu   +17 more
wiley   +1 more source

Field Efficacy of Nicotiana tabacum L. var Virginia Extract against Coffee Borer Beetle (Hypothenemus hampei) Attacking Coffee Berries in Plantation Area

International Journal of Agronomy, Volume 2020, Issue 1, 2020., 2020
The extract of Nicotiana tabacum L. var Virginia origin of Ponorogo (EHRE‐Nt) was applied under field conditions against the coffee borer beetle Hypothenemus hampei (CBB). Three extract formulations containing 150, 300, and 450 ml of EHRE‐Nt in 100 liters of water were prepared and sprayed on 0.5 hectares each.
Andre Fahriz Perdana Harahap, Ahmad Fauzantoro, Haryuni Haryuni, Tyas Sumarah Koernia Dewi, Endang Suprapti, Muhammad Yusuf Arya Ramadhan, Young Je Yoo, Misri Gozan, Yong In Kuk   +8 more
wiley   +1 more source

Beneficial Effects of Concentrated Growth Factors and Resveratrol on Human Osteoblasts In Vitro Treated with Bisphosphonates

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
Bisphosphonates are primary pharmacological agents against osteoclast‐mediated bone loss and widely used in the clinical practice for prevention and treatment of a variety of skeletal conditions, such as low bone density and osteogenesis imperfecta, and pathologies, such as osteoporosis, malignancies metastatic to bone, Paget disease of bone, multiple ...
Elisa Borsani, Veronica Bonazza, Barbara Buffoli, Pier Francesco Nocini, Massimo Albanese, Francesca Zotti, Francesco Inchingolo, Rita Rezzani, Luigi F. Rodella, Mirella Falconi   +9 more
wiley   +1 more source