Results 91 to 100 of about 237,126 (244)

Angiogenesis and targeted therapy in the tumour microenvironment: From basic to clinical practice

Clinical and Translational Medicine, Volume 15, Issue 4, April 2025.
Angiogenesis plays a key role in tumour progression, invasion and metastasis, so strategies targeting angiogenesis are gradually becoming an important direction in cancer therapy. Interactions between endothelial cells and stromal cells and immune cells in the tumour microenvironment are significant in angiogenesis.
Shuaixi Yang, Yingshuai Fang, Yangcheng Ma, Fuqi Wang, Yuhang Wang, Jiachi Jia, Yabing Yang, Weipeng Sun, Quanbo Zhou, Zhen Li   +9 more
wiley   +1 more source

Beyond Poliomyelitis: A 21-Year Study of Non-Polio Enterovirus Genotyping and Its Relevance in Acute Flaccid Paralysis in São Paulo, Brazil

Viruses
In the context of the near-global eradication of wild poliovirus, the significance of non-polio enteroviruses (NPEVs) in causing acute flaccid paralysis (AFP) and their impact on public health has gained increased attention. This research, conducted from
Rita Cássia Compagnoli Carmona, Fabricio Caldeira Reis, Audrey Cilli, Juliana Monti Maifrino Dias, Bráulio Caetano Machado, Daniele Rita de Morais, Adriana Vieira Jorge, Amanda Meireles Nunes Dias, Cleusa Aparecida de Sousa, Sabrina Bonetti Calou, Gabriel Henriques Ferreira, Lucas Leme, Maria do Carmo Sampaio Tavares Timenetsky, Maria Bernadete de Paula Eduardo   +13 more
doaj   +1 more source

IMMUNOPROPHYLAXY OF POLYOMYELITIS: FROM THE FIRST INACTIVE TO THE LAST PERORAL VACCINE, OR HOW CLOSE IS THE «END OF THE GAME»?

Медицинский совет, 2018
Vaccination is the most important tool for combating infectious diseases. There are a number of major vaccine-preventable diseases included in the national calendar of preventive vaccinations Russian Federation (latest revision is regulated by Decree of ...
O. A. Rychkova, M. A. Grakhova
doaj   +1 more source

Cutaneous reactions to vaccination

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 2, Page 195-209, February 2025.
Summary Vaccination is a fundamental principle of preventive health care. Administration of the vaccine, which contains the antigen(s) of a pathogen, activates the immune system and provides protection against infection. The immunogenicity and allergenicity of a vaccine may lead to various adverse reactions, depending on the responsiveness and ...
Jacqueline Kussini, Stefan Mühlenbein, Dario Didona, Wolfgang Pfützner   +3 more
wiley   +1 more source

Disease eradication as a public health strategy: a case study of poliomyelitis eradication

Bulletin of the World Health Organization, 2000
Disease eradication as a public health strategy was discussed at international meetings in 1997 and 1998. In this article, the ongoing poliomyelitis eradication initiative is examined using the criteria for evaluating candidate diseases for eradication ...
R.B. Aylward, H.F. Hull, S.L. Cochi, R.W. Sutter, J.-M. Olivé, B. Melgaard   +5 more
doaj  

Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine

Nature Communications, 2017
Despite the success of current vaccination against poliomyelitis, safe, cheap and effective vaccines remain sought for continuing eradication effort. Here the authors use plants to express stabilized virus-like particles of type 3 poliovirus that can ...
Johanna Marsian, Helen Fox, Mohammad W. Bahar, Abhay Kotecha, Elizabeth E. Fry, David I. Stuart, Andrew J. Macadam, David J. Rowlands, George P. Lomonossoff   +8 more
doaj   +1 more source

Partial Proportional Odds of Child Polio Vaccination Status Among Children Aged 12–23 Months in Ethiopia

Advances in Public Health, Volume 2025, Issue 1, 2025.
Background: The poliovirus is mostly transmitted by the fecal–oral route and can cause viremia after replication in the gastrointestinal tract. The current global coverage of polio immunization is 85%, against the 90% target, while the total coverage of inactivated polio vaccine (IPV) coverage in sub‐Saharan Africa is 73%.
Alebachew Taye Belay, Denekew Bitew Belay, Seyifemickael Amare Yilema, Yikeber Abebaw Moyehodie, Yibo Wu   +4 more
wiley   +1 more source

Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape. [PDF]

, 2020
Vaccination has essentially eradicated poliovirus. Yet, its mutation rate is higher than that of viruses like HIV, for which no effective vaccine exists.
Barton, John P, Chakraborty, Arup K, McKay, Matthew R, Quadeer, Ahmed A   +3 more
core   +3 more sources

Emerging Therapeutics in the Fight Against EV‐D68: A Review of Current Strategies

Influenza and Other Respiratory Viruses, Volume 18, Issue 12, December 2024.
ABSTRACT Enterovirus‐D68 (EV‐D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV‐D68 was underestimated due to limited data and serotyping methods. In 2014, the United States experienced outbreaks of acute flaccid myelitis (AFM) in children EV‐D68 positive.
Nida Kalam, Vinod R. M. T. Balasubramaniam   +1 more
wiley   +1 more source

Endgame for polio eradication? Options for overcoming social and political factors in the progress to eradicating polio. [PDF]

, 2015
In 1988, the Global Polio Eradication Initiative (GPEI) was launched with the goal of eradicating polio by the year 2000. After 25 years, several dynamics still challenge this large public health campaign with new cases of polio being reported annually ...
Ganapathiraju, Pavan, Morssink, Christiaan B, Plumb, James D   +2 more
core   +2 more sources