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Lancet, The, 2022 BACKGROUND The international spread of poliovirus exposes all countries to the risk of outbreaks and is designated a Public Health Emergency of International Concern by WHO. This risk can be exacerbated in countries using inactivated polio vaccine, which
Dimitra Klapsa +2 more
exaly +2 more sources
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Journal of Controlled Release, 2019
The cessation of the oral poliovirus vaccine (OPV) and the inclusion of inactivated poliovirus (IPV) into all routine immunization programmes, strengthens the need for new IPV options.
Agnese Donadei +6 more
semanticscholar +1 more source
The cessation of the oral poliovirus vaccine (OPV) and the inclusion of inactivated poliovirus (IPV) into all routine immunization programmes, strengthens the need for new IPV options.
Agnese Donadei +6 more
semanticscholar +1 more source
2004
Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central nervous system (CNS). A killed and an oral live attenuated vaccine were both developed in the 1950s (Salk 1955; Sabin and Boulger 1973), and subsequent massive vaccination campaigns resulted in near total eradication of PV from most industrialized countries:
Blondel, B. +4 more
openaire +3 more sources
Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central nervous system (CNS). A killed and an oral live attenuated vaccine were both developed in the 1950s (Salk 1955; Sabin and Boulger 1973), and subsequent massive vaccination campaigns resulted in near total eradication of PV from most industrialized countries:
Blondel, B. +4 more
openaire +3 more sources
Annual Review of Genetics, 1993
INFECTIOUS eDNA AND IN VITRO SYNTHESIS OF INFECTIOUS VIRAL RNA 359 SELECTION AND GENERATION OF MUTANTS . . . . . . .... . . .. . . .. . . 360 Selection of Spontaneous Mutants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 363 Random Mutagenesis .... _ . . . . . . . _ _ .... ... ... _ _ . . . . . . . . . 370 Mutagenesis Targeted to Existing
E, Wimmer, C U, Hellen, X, Cao
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INFECTIOUS eDNA AND IN VITRO SYNTHESIS OF INFECTIOUS VIRAL RNA 359 SELECTION AND GENERATION OF MUTANTS . . . . . . .... . . .. . . .. . . 360 Selection of Spontaneous Mutants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 363 Random Mutagenesis .... _ . . . . . . . _ _ .... ... ... _ _ . . . . . . . . . 370 Mutagenesis Targeted to Existing
E, Wimmer, C U, Hellen, X, Cao
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Biochemical and Biophysical Research Communications, 1972
Summary Poliovirus, dissociated by exposure to 9 M urea and 0.09 M mercaptoethanol into RNA and protein, can be reconstituted to infectious viral particles by stepwise dilution with cold isotonic phosphate buffered saline at pH 7.2.
R, Drzeniek, P, Bilello
openaire +2 more sources
Summary Poliovirus, dissociated by exposure to 9 M urea and 0.09 M mercaptoethanol into RNA and protein, can be reconstituted to infectious viral particles by stepwise dilution with cold isotonic phosphate buffered saline at pH 7.2.
R, Drzeniek, P, Bilello
openaire +2 more sources
Trends in Biotechnology, 1991
Poliovirus, the aetiological agent of paralytic poliomyelitis, is arguably the best characterized of all animal viruses. Using recombinant-DNA technology, this information, together with the availability of infectious cDNA clones of the notably safe and efficacious live attenuated Sabin 1 vaccine strains of poliovirus, has enabled the creation of ...
C S, Rose, D J, Evans
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Poliovirus, the aetiological agent of paralytic poliomyelitis, is arguably the best characterized of all animal viruses. Using recombinant-DNA technology, this information, together with the availability of infectious cDNA clones of the notably safe and efficacious live attenuated Sabin 1 vaccine strains of poliovirus, has enabled the creation of ...
C S, Rose, D J, Evans
openaire +2 more sources
Clinical Infectious Diseases, 1984
Most of the poliovirus vaccine distributed in the United States since 1962 has been of the live, oral type ( OPV ). Production problems have not been a major concern for the manufacturer. The statistics compiled by various authorities since the product was introduced relative to paralytic disease following the administration of OPV are discussed and ...
openaire +2 more sources
Most of the poliovirus vaccine distributed in the United States since 1962 has been of the live, oral type ( OPV ). Production problems have not been a major concern for the manufacturer. The statistics compiled by various authorities since the product was introduced relative to paralytic disease following the administration of OPV are discussed and ...
openaire +2 more sources