Results 151 to 160 of about 6,964,283 (298)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Crisis Resource Management and Non-Technical Skills Training in Anesthesia: A Narrative Review. [PDF]

Med Sci Monit
Rabijewski M, Kurek A, Muża M, Paszek S, Frączek Z, Rabijewski M.   +5 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Social Media and out of Home Food Selection and Health Promoting Choices: A Generational Perspective in Poland. [PDF]

Nutrients
Soroka A, Godlewska A, Mazurek-Kusiak AK.   +2 more
europepmc   +1 more source

Ethical Foreground and Background in Adult Educator Work

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

Polish literature in lithuanian and the lithuanian literature in polish languages (1991-2006)

, 2008
Straipsnyje pateikiami nauji lyginamųjų literatūrologinių tyrimų duomenys apie lenkų literatūrą lietuvių kalba ir lietuvių literatūrą lenkų kalba, išleistą per paskutinius penkiolika metų.
Dalecka, Teresa
core  

Effect of multi-system polishing on shear bond strength of nanohybrid composites to enamel: an <i>in vitro</i> study. [PDF]

PeerJ
Alsaeed A, Arora S, Rubayan BM, Abdelaziz KM, Alshahrani MA, Fae AM, AlShahrani M, Alshahrani AY, Bhardwaj A, Patro S, Pawar AM.   +10 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

The lives of young Polish migrants residing in Northamptonshire [PDF]

This thesis investigates the lives of young Polish migrants living in Northamptonshire, who migrated to the UK following Poland’s accession to the European Union in May 2004. Over 1.1 million Worker Registration Scheme (WRS) applications were made in the
Callender, Matthew
core