Results 91 to 100 of about 20,398,982 (293)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Building Social Capital in the Polish-German border region: An Evaluation of the effectiveness of EU-funded Small Projects [PDF]

, 2014
Our research examines the development of 'social capital' in border regions. Specifically, we analyse whether participating in social or cultural events such as creative workshops or sporting competitions – so-called small projects – promotes ...
Płoszaj, A, Sarmiento-Mirwaldt, K
core   +3 more sources

“A History of Polish Art” by Michał Walicki and Juliusz Starzyński in Poland between the World Wars. The West, Poland, the East

Artium Quaestiones, 2019
Writing an academic history of Polish art was an urgent task of art historians after World War I, when the country regained its political independence.
Adam S. Labuda
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Wokół nowoczesnych konsekwencji romantyzmu w polskiej historiografii

Litteraria Copernicana, 2008
Author’s ambition is arousing interest of forms of reception of the Middle Ages, which there are in scientific literature, popular lecture and general, social awareness.
Jarosław Wenta
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Tracing the journey of cross-cultural adaptation of Polish migrant women in Ireland - a process of creating home when home is away. [PDF]

, 2008
This study traces the journey of cross-cultural adaptation of Polish migrant women in Ireland, which turns out to be a process of creating home when home is away, and which results in individual identity transformations, both positive and negative. It is
Storch, Katharina
core   +3 more sources

Architektura, nacjonalizm i „reakcyjny modernizm”. Głos krytyczny

Miejsce, 2015
The essay reviews two recent initiatives connected with interwar Polish politics and its relations to the broad field of culture/architecture of the period.
Makary Górzyński
doaj  

A diagnosis of strangeness. Brzozowski’s Anti-Sienkiewicz campaign as a dispute about Polish identity

Poznańskie Studia Polonistyczne. Seria Literacka, 2016
This essay discusses the Anti-Sienkiewicz campaign briefly. The affair happened in 1903 in the Warsaw weekly magazine “Głos”, but was written up in many Polish newspapers.
Krzysztof Fiołek
doaj   +1 more source