Results 151 to 160 of about 29,047 (207)

The ultimate forgery: A semiotic deconstruction of large language models as engines of simulated selfhood

Journal of the Association for Information Science and Technology, EarlyView.
Abstract Information science rests on a compact: its mediating signs maintain a traceable relation to what they describe. Large language models (LLMs) break it architecturally, generating discourse that is statistically plausible yet epistemically ungrounded, while standard metrics (precision, recall, relevance) cannot detect the rupture.
Martin Thellefsen, Alon Friedman
wiley   +1 more source

Did AI win after all?

Journal of the Association for Information Science and Technology, EarlyView.
Abstract Algorithmic platforms are reshaping how people work and how human activity is rendered intelligible within data‐intensive systems. This paper argues that Heidegger's philosophy of technology, specifically Ge‐stell (enframing) and Poiesis (bringing‐forth), offers information science a conceptual vocabulary for understanding both algorithmic ...
Fred Fonseca
wiley   +1 more source

Confronting corporate power: addressing commercial determinants of health and the rising non-communicable disease epidemic in South-East Asia. [PDF]

BMJ Glob Health
Bassi S, Gupta SK, Rajkhowa P, Marten R, Good S, Arora M.   +5 more
europepmc   +1 more source

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Digital determinants of nutrition: the case for a distinct domain to guide health promotion research and policy. [PDF]

Health Promot Int
Agarwal K, Holly L.
europepmc   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Redefining Regulatory Proof: The End of the Two-Trial Paradigm. [PDF]

Fundam Clin Pharmacol
Lega JC, Provencher S, Falissard B, Locher C, Roustit M, Gougeon A, Boussageon R, Chevret S.   +7 more
europepmc   +1 more source

String Figuring young children's perspectives of quality in English early childhood education and care

British Educational Research Journal, EarlyView.
Abstract Quality in early childhood education and care (ECEC) is a contested concept and has generally been conceptualised by inter‐related indicators such as staff qualifications, educational environment, policy or child‐to‐staff ratios. There has been a more limited emphasis on how young children might perceive and experience quality.
Nikki Fairchild, Éva Mikuska
wiley   +1 more source

Food-environment policies for child nutrition in Ecuador and Latin America: beyond front-of-package labels and advertising restrictions. [PDF]

Lancet Reg Health Am
López-Gil JF, Quiroz-Cárdenas F, López-Moreno M.   +2 more
europepmc   +1 more source