Results 91 to 100 of about 194,833 (307)

Rats or garbage? Dehumanizing politicians through metaphor

open access: yesStudies in English Language and Education
The public often show their disappointment with dishonest politicians through dehumanizing metaphors. This study aimed to analyze the use of metaphors to dehumanize Indonesian politicians on X social media, formerly Twitter.
Novi Eka Susilowati   +2 more
doaj   +1 more source

Paradoxes du stigmate : les représentations médiatiques de Marine Le Pen

open access: yesGenre, Sexualité et Société, 2013
Media representations of female politicians differ from those of men involved in politics. For example, they currenly disadvantage women by linking them to the gender roles of daughter, spouse and mother, invoking skills far removed from the political ...
Frédérique Matonti
doaj   +1 more source

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

open access: yesAdvanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang   +9 more
wiley   +1 more source

“Vote for Me, I Am Authentic”: Performed Political Authenticity on Social Media

open access: yesMedia and Communication
Authenticity has become a key concept in political communication, particularly during election campaigns, which offer opportunities for politicians to strategically convey an authentic image.
Simon M. Luebke, Ines Engelmann
doaj   +1 more source

the Labor Market of Italian Politicians, Second Version [PDF]

open access: yes
We analyze the career profiles of Italian legislators in the post-war period. Using a unique, newly collected dataset that contains detailed information on all the politicians who have been elected to the Italian Parliament between 1948 and 2008, we ...
Vincenzo Galasso   +3 more
core  

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

open access: yesAdvanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li   +9 more
wiley   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

open access: yesAdvanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li   +9 more
wiley   +1 more source

Reasoning Indian Politics: Philosopher Politicians Seeking Philosophy

open access: yes, 2018
This volume examines the multiple forms of reasoning in Indian politics and explores a framework to understand them. In the process, it looks at a series of issues involving the relationship between politics and philosophy, including the status of ...
Behera, Anshuman, Pani, Narendar
core  

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

open access: yesAdvanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang   +11 more
wiley   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li   +9 more
wiley   +1 more source

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