Results 31 to 40 of about 64,580 (314)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Understanding opposition: arguments for and against a meat tax in Sweden and their effect on policy attitudes

Environmental Research: Food Systems
Meat taxes could reduce emissions and improve health but risks facing opposition due to concerns about fairness, effectiveness, and autonomy. While policy-specific beliefs influence attitudes, less is known about how specific arguments in the public ...
E Ejelöv, J Larsson, S Matti, J Nässén   +3 more
doaj   +1 more source

Mental health of high-level politicians: diagnostics, public discussion and treatment―a narrative review

Environmental and Occupational Health Practice, 2020
Objectives: To narratively review the presence and treatments of mental health problems among high-level political leaders. These questions have been noted in few epidemiologically sound studies and in the media.
Matti Isohanni
doaj   +1 more source

Stepping backwards with disability humor? The case of NY Gov. David Paterson’s representation on ‘Saturday Night Live’

Disability Studies Quarterly, 2014
In the modern era, discerning TV viewers know the shows that trade in cheap laughs by making fun of people with disabilities are not tapping into much creativity. So it was a surprise in 2008 when the highly regarded comedy show Saturday Night Live (SNL)
Beth Haller, Amy Bree Becker
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Stalking, harassment, gendered abuse, and violence towards politicians in the COVID-19 pandemic and recovery era

Frontiers in Psychiatry
BackgroundHigh levels of harassment and threats against parliamentarians are being reported internationally, especially in the social media space. This is occurring alongside changes in our social landscape, with increasing political polarisation and the
Susanna Every-Palmer, Susanna Every-Palmer, Oliver Hansby, Oliver Hansby, Justin Barry-Walsh   +4 more
doaj   +1 more source

“This is not a political party, this is Facebook!”: Political jokes and political (mis)trust in crisis-ridden Greece

The European Journal of Humour Research, 2017
The present study attempts to combine Raskin’s (1985) and Davies’ (2011) methodological approaches to political jokes to investigate Greek political jokes targeting politicians and circulated during the first 4 years of the Greek crisis.
Villy Tsakona
doaj   +1 more source